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Interleukin 31 (IL31) (Center) antibody

Details for Product No. ABIN303271, Supplier: Log in to see
Antigen
  • IL31
  • IL-31
  • 1700013B14Rik
Epitope
Center
26
13
9
8
5
5
3
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
88
30
9
Host
Rabbit
95
13
1
Clonality
Polyclonal
Conjugate
Un-conjugated
14
5
4
3
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
72
64
23
17
16
15
5
3
3
2
1
1
Supplier
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Immunogen Synthetic Peptide corresponding to 18 amino acid peptide from near the center of human IL-31.
Specificity This antibody reacts with Interleukin 31 (IL31).
Purification Affinity Chromatography.
Alternative Name Interleukin-31 / IL31 (IL31 Antibody Abstract)
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.Synonyms: IL-31
Gene ID 386653
NCBI Accession NP_001014358
UniProt Q6EBC2
Pathways
Application Notes Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
Supplier Images
 image for anti-Interleukin 31 (IL31) (Center) antibody (ABIN303271) anti-Interleukin 31 (IL31) (Center) antibody
Background publications Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. ..." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).