Interleukin 31 (IL31) (Center) antibody

Details for Product No. ABIN303271
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Antigen
Synonyms IL31, IL-31, 1700013B14Rik
Epitope
Center
(17), (7), (4), (4), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(67), (35), (13)
Host
Rabbit
(85), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(57), (41), (30), (19), (14), (9), (3), (3), (1)
Pubmed 2 references available
Quantity 50 μg
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Request Want additional data for this product?

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Catalog No. ABIN303271
500.50 $
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  • +1 404 474 4654
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Immunogen Synthetic Peptide corresponding to 18 amino acid peptide from near the center of human IL-31.
Specificity This antibody reacts with Interleukin 31 (IL31).
Purification Affinity Chromatography.
Alternative Name Interleukin-31 / IL31
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Alternate names: IL-31
Gene ID 386653
NCBI Accession NP_001014358
UniProt Q6EBC2
Application Notes Immunohistochemistry on Paraffin Sections (5 µg/ml). Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-Interleukin 31 (IL31) (Center) antibody anti-Interleukin 31 (IL31) (Center) antibody
Background publications Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).

Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

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