Interleukin 31 (IL31) (Center) antibody

Details for Product No. ABIN303271
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Antigen
Synonyms IL31, IL-31, 1700013B14Rik
Epitope
Center
(26), (13), (12), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(96), (39), (19)
Host
Rabbit
(117), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(19), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(83), (63), (30), (23), (22), (16), (7), (5), (5), (2), (1)
Pubmed 2 references available
Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Immunogen Synthetic Peptide corresponding to 18 amino acid peptide from near the center of human IL-31.
Specificity This antibody reacts with Interleukin 31 (IL31).
Purification Affinity Chromatography.
Alternative Name Interleukin-31 / IL31 (IL31 Antibody Abstract)
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.Synonyms: IL-31
Gene ID 386653
NCBI Accession NP_001014358
UniProt Q6EBC2
Application Notes Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.
Supplier Images
anti-Interleukin 31 (IL31) (Center) antibody anti-Interleukin 31 (IL31) (Center) antibody
Background publications Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. ..." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).

Validation Images
Catalog No. ABIN303271
500.50 $
Plus shipping costs $45.00
Quantity
Price
50 μg
500.50 $

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