Interleukin 31 (IL31) (Center) antibody

Details for Product No. ABIN303271
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Antigen
Synonyms IL-31, 1700013B14Rik, IL31
Epitope
Center
(12), (4), (4), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(64), (37), (15)
Host
Rabbit
(84), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(57), (48), (30), (22), (11), (6), (4), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN303271
Quantity 50 µg
Price
500.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic Peptide corresponding to 18 amino acid peptide from near the center of human IL-31.
Specificity This antibody reacts with Interleukin 31 (IL31).
Purification Affinity Chromatography.
Alternative Name Interleukin-31 / IL31
Background Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
Alternate names: IL-31
Gene ID 386653
NCBI Accession NP_001014358.1
UniProt Q6EBC2
Application Notes Immunohistochemistry on Paraffin Sections (5 µg/ml). Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-Interleukin 31 (IL31) (Center) antibody anti-Interleukin 31 (IL31) (Center) antibody
Background publications Dillon, Sprecher, Hammond et al.: "Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice." in: Nature immunology, Vol. 5, Issue 7, pp. 752-60, 2004 (PubMed).

Bilsborough, Leung, Maurer et al.: "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis." in: The Journal of allergy and clinical immunology, Vol. 117, Issue 2, pp. 418-25, 2006 (PubMed).

Hosts (84), (5)
Reactivities (64), (37), (15)
Applications (57), (48), (30), (22), (11), (6), (4), (3), (2), (1), (1)
Conjugates (10), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (12), (4), (4), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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