Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot (1-2 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3,4). Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.Synonyms: IRF-7, Interferon regulatory factor 7