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serine/threonine Kinase 17b (STK17B) (AA 351-365) antibody

Details for Product No. ABIN303291
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Antigen
Synonyms DRAK2, Drak2, 3110009A03Rik, AI120141, zgc:65989, STK17B
Epitope
AA 351-365
(29), (8), (8), (7), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(77), (21), (19), (13), (12), (12)
Host
Rabbit
(66), (9), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(57), (32), (21), (10), (10), (10), (7), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN303291
500.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic Peptide - KLH conjugated corresponding to Amino Acids 351-365 of Human DRAK2.
Specificity This antibody is specific for DRAK2.
Purification Ion Exchange chromatography.
Alternative Name STK17B / DRAK2
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase related apoptosis inducing protein kinases). DRAKs contain an N terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues. Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP,are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis- inducing protein kinases). DRAKs contain anN-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Alternate names: DAP kinase-related apoptosis-inducing protein kinase 2, Serine/threonine-protein kinase 17B
Gene ID 9262
NCBI Accession NP_004217.1
UniProt O94768
Application Notes Immunohistochemistry on Paraffin Sections (5 µg/ml). Immunocytochemistry. Western Blot (1/500-1/1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C to -70°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-serine/threonine Kinase 17b (STK17B) (AA 351-365) antibody anti-serine/threonine Kinase 17b (STK17B) (AA 351-365) antibody
Background publications Kawai, Matsumoto, Takeda et al.: "ZIP kinase, a novel serine/threonine kinase which mediates apoptosis." in: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1642-51, 1998 (PubMed).

Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN303291
500.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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