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SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody

Details for Product No. ABIN303292
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Antigen
Synonyms
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI78975 ... show more
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\\CG4494, Dmsmt3, SMT3, SUMO, Smt3, Sumo, anon-EST:Posey240, dSmt3, dsmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, sumo, SUMO1, sumo-1, sumo1, 4921531N22Rik, AI789753, AU040360, DAP-1, Gkap, DAP1, GMP1, OFC10, PIC1, SENP2, SMT3C, SMT3H3, UBL1, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1, ATSUMO1, F10M23.180, F10M23_180, SMALL UBIQUITIN-LIKE MODIFIER 1, SUM1, SUMO 1, small ubiquitin-like modifier 1, pigSUMO1, SENTRIN, SMTP3, SUMO-1, Smt3C, Ubl1, hm:zeh0670, wu:fb74c02, wu:fd12c02, zgc:65934, zgc:85634 show less
Epitope
N-Term
(23), (11), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(141), (68), (63), (23), (23), (12), (11), (2), (1), (1), (1), (1)
Host
Rabbit
(123), (22), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(117), (55), (44), (34), (29), (29), (27), (20), (4), (3), (1)
Pubmed 5 references available
Quantity 50 µg
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Request Want additional data for this product?

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Catalog No. ABIN303292
500.50 $
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Immunogen Synthetic peptide corresponding to 14 amino acid peptide from near the amino terminus of human sumo
Specificity This antibody recognises SUMO1.
Purification Purified
Alternative Name SUMO1
Background The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2, and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. The unconjugated SUMO-1, 2, and 3 proteins are approximately 11 kDa in mass and localize to the nuclear membrane, nuclear bodies, and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkappaBalpha, MDM2, p53, PML, and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates Amyloid beta generation and may be critical in the onset or progression of Alzheimer’s disease
Alternate names: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin- related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1
Gene ID 7341
NCBI Accession NP_001005781.1
UniProt P63165
Research Area Signaling, Proteases, DNA/RNA
Application Notes Immunohistochemistry on paraffin sections (5 µg/ml). Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate Buffered Saline (PBS) containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer. Dilute only prior to immediate use.
Expiry Date 12 months
Supplier Images
anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody
anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody (2) anti-SMT3 Suppressor of Mif Two 3 Homolog 1 (S. Cerevisiae) (SUMO1) (N-Term) antibody (Image 2)
Background publications Ohshima, Shimotohno: "Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 50833-42, 2003 (PubMed).

Bailey, OHare: "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 692-703, 2003 (PubMed).

Pountney, Huang, Burns et al.: "SUMO-1 marks the nuclear inclusions in familial neuronal intranuclear inclusion disease." in: Experimental neurology, Vol. 184, Issue 1, pp. 436-46, 2003 (PubMed).

Ling, Sankpal, Robertson et al.: "Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription." in: Nucleic acids research, Vol. 32, Issue 2, pp. 598-610, 2004 (PubMed).

Yang, Sharrocks: "SUMO promotes HDAC-mediated transcriptional repression." in: Molecular cell, Vol. 13, Issue 4, pp. 611-7, 2004 (PubMed).

Validation Images
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