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TUBA1B antibody (Biotin)

TUBA1B Reactivity: Pig WB Host: Mouse Monoclonal TU-01 Biotin
Catalog No. ABIN303511
  • Target See all TUBA1B Antibodies
    TUBA1B (Tubulin, alpha 1B (TUBA1B))
    Reactivity
    • 45
    • 25
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Pig
    Host
    • 36
    • 11
    • 1
    Mouse
    Clonality
    • 34
    • 14
    Monoclonal
    Conjugate
    • 26
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TUBA1B antibody is conjugated to Biotin
    Application
    • 43
    • 20
    • 17
    • 14
    • 13
    • 10
    • 7
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    The antibody TU-01 recognizes the defined epitope (aa 65-97) on N-terminal structural domain of alpha-tubulin.
    Immunogen
    Fraction of tubulin purified from porcine brain by two cycles of polymerization - depolymerization.
    Clone
    TU-01
    Isotype
    IgG1
    Top Product
    Discover our top product TUBA1B Primary Antibody
  • Application Notes
    Western Blotting (1/1000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH ~7.4, 15 mM Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.
  • Target
    TUBA1B (Tubulin, alpha 1B (TUBA1B))
    Alternative Name
    alpha Tubulin / TUBA1B (TUBA1B Products)
    Synonyms
    RGD1565476 antibody, K-ALPHA-1 antibody, cb944 antibody, fb22g06 antibody, tuba1 antibody, wu:fb22g06 antibody, Tuba2 antibody, TUBA3 antibody, k-alpha-1 antibody, tuba antibody, Calpha1 antibody, Tuba1 antibody, TUBA1B antibody, tubulin, alpha 1B antibody, tubulin alpha 1b antibody, tubulin, alpha 1b antibody, tubulin alpha 1b L homeolog antibody, tubulin alpha-1B chain antibody, Tubulin alpha-1B chain antibody, Tuba1b antibody, TUBA1B antibody, tuba1b antibody, tuba1b.L antibody, LOC100445003 antibody, LOC102178700 antibody
    Background
    The microtubules are intracellular dynamic polymers made up of evolutionarily conserved polymorphic alpha/beta-tubulin heterodimers and a large number of microtubule-associated proteins (MAPs). The microtubules consist of 13 protofilaments and have an outer diameter 25 nm. Microtubules have their intrinsic polarity, highly dynamic plus ends and less dynamic minus ends. Microtubules are required for vital processes in eukaryotic cells including mitosis, meiosis, maintenance of cell shape and intracellular transport. Microtubules are also necessary for movement of cells by means of flagella and cilia. In mammalian tissue culture cells microtubules have their minus ends anchored in microtubule organizing centers (MTOCs).The GTP (guanosintriphosphate) molecule is an essential for tubulin heterodimer to associate with other heterodimers to form microtubule. In vivo, microtubule dynamics vary considerably. Microtubule polymerization is reversible and a populations of microtubules in cells are on their minus ends either growing or shortening - this phenomenon is called dynamic instability of microtubules. On a practical level, microtubules can easily be stabilized by the addition of non-hydrolysable analogues of GTP (eg. GMPPCP) or more commonly by anti-cancer drugs such as Taxol. Taxol stabilizes microtubules at room temperature for many hours. Using limited proteolysis by enzymes both tubulin subunits can be divided into N-terminal and C-terminal structural domains. The alpha-tubulin (relative molecular weight around 50 kDa) is globular protein that exists in cells as part of soluble alpha/beta-tubulin dimer or it is polymerized into microtubules. In different species it is coded by multiple tubulin genes that form tubulin classes (in human 6 genes). Expressed tubulin genes are named tubulin isotypes. Some of the tubulin isotypes are expressed ubiquitously, while some have more restricted tissue expression. Alpha-tubulin is also subject of numerous post-translational modifications. Tubulin isotypes and their posttranslational modifications are responsible for multiple tubulin charge variants - tubulin isoforms. Heterogeneity of alpha-tubulin is concentrated in C-terminal structural domain.Synonyms: Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-1B chain, Tubulin alpha-ubiquitous chain
    Gene ID
    10376
    NCBI Accession
    NP_006073
    UniProt
    P68363
    Pathways
    Microtubule Dynamics, M Phase
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