BASKET
HELP
SHOW TUTORIAL VIDEOShow Search Tutorial Video
(requires Flash, opens in new window)
Show Search Tutorial Video
(requires Flash, opens in new window)
(requires Flash, opens in new window)
Show Search Tutorial Video(requires Flash, opens in new window)
Product Details
anti-Oazin (Antizyme inhibitor 1) antibody
Overview
| Antigen: | Oazin (Antizyme inhibitor 1) |
| Clonality: | Monoclonal (HI-12) |
| Application: | Western Blotting (WB), Immunocytochemistry (ICC) |
| Reactivity: | Human, Mouse (Murine), Rat (Rattus) |
| Host: | Mouse |
| Quantity: | |
| Price: | 884,12 $ (Plus shipping costs $25 and VAT, Invoice in EUR) |
| Order number: | ABIN303592 |
| Availability: | Ships within 5 Business days |
Customer Service
Additional Information » anti-Oazin (Antizyme inhibitor 1) antibody
| Antigen | Oazin (Antizyme inhibitor 1) |
| Immunogen | Affinity-purified Antizyme inhibitor from rat liver |
| Reactivity | Human, Mouse (Murine), Rat (Rattus) |
| Clonality | Monoclonal |
| Format | Ion exchange chromatography |
| Isotype | IgG3 »Matching secondary antibodies |
| Description | ODC (ornithine decarboxylase) is a key enzyme in polyamine biosynthesis pathway. The degradation of ODC catalyzed by the 26S proteasome is accelerated by antizyme, an ODC inhibitory protein induced poliamine. Antizyme inhibitor 1 (AZI) specifically binds to antizyme with a higher affinity than that of ODC and thus can release active ODC from inactive ODC-antizyme complex. AZI consists of about 450 amino acids and 50 kDa protein. AZI is highly homologous to ODC but retains no enzymatic activity. AZI is a short-living protein that undergoes proteasomal degradation and the degradation is inhibited by interaction with antizyme. AZI is induced in cells and tissues following growth stimulation, is elevated in some tumors. AZI overexpression leads to increased rates of cell proliferation in the rat carcinoma cells and mouse fibroblasts and this effect appears to be partially independent of the ability of AZI to interact with antizyme. It has been also reported that antizyme and AZI localize to centrosome and may play an important role in the regulation of centrosome homeostasis and oncogenesis. |
| Clone | HI-12 |
| Host | Mouse |
Application Details » anti-Oazin (Antizyme inhibitor 1) antibody
| Application |
Western Blotting (WB), Immunocytochemistry (ICC)
» Click here to view 2 available protocols! |
| Application Notes | WB: 0.25 ug/mL. ICC 30 ug/mL |
| Concentration | 0.25 mg/ml |
| Purification | Ion exchange chromatography |
| Buffer | PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat] |
| Storage | Store below |
| Research Area | Enzymes, Metabolism, Proteasome |
| Restrictions | For Research Use only |
Images » anti-Oazin (Antizyme inhibitor 1) antibody
|
|
browse antibodies by
Antigens
Secondary Antibodies
Research Areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research Areas
Clones
Hosts
Applications
Reactivity
Supplier
