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EGFR antibody (AA 25-346)

EGFR Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3042517
  • Target See all EGFR Antibodies
    EGFR (Epidermal Growth Factor Receptor (EGFR))
    Binding Specificity
    • 41
    • 39
    • 39
    • 38
    • 35
    • 28
    • 27
    • 27
    • 22
    • 21
    • 19
    • 19
    • 18
    • 17
    • 16
    • 16
    • 15
    • 15
    • 15
    • 14
    • 14
    • 13
    • 13
    • 11
    • 11
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    AA 25-346
    Reactivity
    • 820
    • 326
    • 317
    • 26
    • 26
    • 24
    • 20
    • 15
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 649
    • 174
    • 14
    • 11
    • 5
    • 1
    Rabbit
    Clonality
    • 597
    • 252
    • 2
    Polyclonal
    Conjugate
    • 429
    • 65
    • 33
    • 30
    • 29
    • 29
    • 29
    • 27
    • 27
    • 26
    • 23
    • 17
    • 10
    • 10
    • 10
    • 10
    • 10
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This EGFR antibody is un-conjugated
    Application
    • 577
    • 262
    • 146
    • 144
    • 137
    • 101
    • 101
    • 96
    • 81
    • 55
    • 37
    • 34
    • 34
    • 18
    • 10
    • 8
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Epidermal growth factor receptor(EGFR) detection. Tested with WB in Human,Rat.
    Brand
    Picoband™
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Epidermal growth factor receptor(EGFR) detection. Tested with WB in Human,Rat.
    Gene Name: epidermal growth factor receptor
    Protein Name: Epidermal growth factor receptor
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human EGFR recombinant protein (Position: L25-K346). Human EGFR shares 89% amino acid (aa) sequence identity with mouse EGFR.
    Isotype
    IgG
    Top Product
    Discover our top product EGFR Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Hao, Yang, Ding, Guo, Zhu, Ji, Zhou, Wu: "Paeoniflorin Potentiates the Inhibitory Effects of Erlotinib in Pancreatic Cancer Cell Lines by Reducing ErbB3 Phosphorylation." in: Scientific reports, Vol. 6, pp. 32809, (2018) (PubMed).

    Shangguan, Jiang, Pan, Xiao, Tan, Tie, Qin, Deng, Chen, Wang: "Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats." in: Cell death & disease, Vol. 8, Issue 10, pp. e3157, (2018) (PubMed).

    Cheng, Li, Liu, Cheng, Ma, Qiu: "YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition." in: Chinese journal of cancer, Vol. 31, Issue 5, pp. 248-56, (2013) (PubMed).

    Yue, Gao, Xue, Cui, Zhao, Yuan, Yin, Inagaki, Kokudo, Tang, Qu: "Des-?-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway." in: European journal of cancer (Oxford, England : 1990), Vol. 47, Issue 7, pp. 1115-24, (2011) (PubMed).

    Gu, Zhang, Wu, Xu, Cui, Yang, Zhao, Sun: "Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer." in: Journal of experimental & clinical cancer research : CR, Vol. 29, pp. 6, (2010) (PubMed).

    Ge, Yu, Petitte, Zhang: "Epidermal growth factor-induced proliferation of chicken primordial germ cells: involvement of calcium/protein kinase C and NFKB1." in: Biology of reproduction, Vol. 80, Issue 3, pp. 528-36, (2009) (PubMed).

    Wang, Cheng, Cui, Zhong, Ward, Sun, Chen, Kokudo, Tang, Qu: "Des-gamma-carboxy prothrombin stimulates human vascular endothelial cell growth and migration." in: Clinical & experimental metastasis, Vol. 26, Issue 5, pp. 469-77, (2009) (PubMed).

  • Target
    EGFR (Epidermal Growth Factor Receptor (EGFR))
    Alternative Name
    EGFR (EGFR Products)
    Synonyms
    C-erb antibody, CG10079 antibody, D-EGFR antibody, D-Egf antibody, DEGFR antibody, DER antibody, DER flb antibody, DER/EGFR antibody, DER/faint little ball antibody, DER/top antibody, DER/torpedo antibody, DER1 antibody, DEgfr antibody, Degfr antibody, Der antibody, DmHD-33 antibody, Dmel\\CG10079 antibody, EFG-R antibody, EGF-R antibody, EGFR antibody, EGFr antibody, EGfr antibody, EK2-6 antibody, Egf antibody, Egf-r antibody, EgfR antibody, El antibody, Elp antibody, Elp-1 antibody, Elp-B1 antibody, Elp-B1RB1 antibody, HD-33 antibody, TOP antibody, Torpedo/DER antibody, Torpedo/Egfr antibody, c-erbB antibody, d-egf-r antibody, dEGFR antibody, dEGFR1 antibody, dEgfr antibody, der antibody, egfr antibody, flb antibody, l(2)05351 antibody, l(2)09261 antibody, l(2)57DEFa antibody, l(2)57EFa antibody, l(2)57Ea antibody, mor1 antibody, top antibody, top/DER antibody, top/flb antibody, torpedo/Egfr antibody, torpedo/egfr antibody, EGFR12 antibody, EGFR15 antibody, egfr1 antibody, Erbb2 antibody, ERBB antibody, ERBB1 antibody, HER1 antibody, PIG61 antibody, mENA antibody, ErbB-1 antibody, Errp antibody, 9030024J15Rik antibody, AI552599 antibody, Erbb antibody, Errb1 antibody, Wa5 antibody, wa-2 antibody, wa2 antibody, epidermal growth factor receptor antibody, Epidermal growth factor receptor antibody, epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) antibody, EGFR antibody, Egfr antibody, egfra antibody, egfr1 antibody, LOC5564544 antibody
    Background
    The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.

    Synonyms: Avian erythroblastic leukemia viral (v erb b) oncogene homolog antibody|Avian erythroblastic leukemia viral (verbb) oncogene homolog antibody|Cell growth inhibiting protein 40 antibody|Cell proliferation inducing protein 61 antibody|EGF R antibody|EGFR antibody|EGFR_HUMAN antibody|Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) antibody|Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian) antibody|Epidermal growth factor receptor antibody|erbb 1 antibody|Erbb antibody|Erbb1 antibody|ERBB1 antibody|Errp antibody|HER1 antibody|mENA antibody|Oncogene ERBB antibody|PIG61 antibody|Proto-oncogene c-ErbB-1 antibody|Receptor tyrosine protein kinase ErbB 1 antibody|Receptor tyrosine protein kinase ErbB1 antibody|Receptor tyrosine-protein kinase ErbB-1 antibody|Urogastrone antibody|wa2 antibody|Wa5 antibody
    Gene ID
    1956
    UniProt
    P00533
    Pathways
    NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
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