Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Caspase 8 antibody (AA 388-480)

CASP8 Reactivity: Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3042601
  • Target See all Caspase 8 (CASP8) Antibodies
    Caspase 8 (CASP8)
    Binding Specificity
    • 16
    • 16
    • 10
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 388-480
    Reactivity
    • 136
    • 69
    • 63
    • 23
    • 16
    • 16
    • 10
    • 1
    • 1
    • 1
    Mouse
    Host
    • 129
    • 24
    • 5
    • 2
    Rabbit
    Clonality
    • 126
    • 33
    Polyclonal
    Conjugate
    • 95
    • 16
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 8 antibody is un-conjugated
    Application
    • 141
    • 50
    • 44
    • 38
    • 27
    • 26
    • 25
    • 21
    • 19
    • 18
    • 8
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Caspase-8(CASP8) detection. Tested with WB in Mouse.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Caspase-8(CASP8) detection. Tested with WB in Mouse.
    Gene Name: caspase 8, apoptosis-related cysteine peptidase
    Protein Name: Caspase-8
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived mouse Caspase 8 recombinant protein (Position: S388-P480). Mouse Caspase 8 shares 83% amino acid (aa) sequence identity with human Caspase 8.
    Isotype
    IgG
    Top Product
    Discover our top product CASP8 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, The detection limit for Caspase 8 is approximately 0.1 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Zhan, Hu, Yi, An, Huang: "[Corrigendum] Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo." in: Molecular medicine reports, Vol. 17, Issue 6, pp. 8010, (2018) (PubMed).

    Zhou, He, Wang, Xie, Liu, Liu, Song, Ma: "Intravenous Administration Is an Effective and Safe Route for Cancer Gene Therapy Using the Bifidobacterium-Mediated Recombinant HSV-1 Thymidine Kinase and Ganciclovir." in: International journal of molecular sciences, Vol. 17, Issue 6, (2017) (PubMed).

    Zhang, Huang, Wang, Luo, Wang: "2-DG-Regulated RIP and c-FLIP Effect on Liver Cancer Cell Apoptosis Induced by TRAIL." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 21, pp. 3442-8, (2016) (PubMed).

    Li, Wu, Sun, Zhao, Liu, Zhang: "Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Cancer A549 Cells" in: Asian Pacific journal of cancer prevention : APJCP, Vol. 17, Issue 11, pp. 4893-4898, (2016) (PubMed).

    Zhan, Hu, Yi, An, Huang: "Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo." in: Molecular medicine reports, Vol. 11, Issue 6, pp. 4142-8, (2015) (PubMed).

    Liu, Chen, Wang, Yang, Xue, Zhu: "Msi1 confers resistance to TRAIL by activating ERK in liver cancer cells." in: FEBS letters, Vol. 589, Issue 8, pp. 897-903, (2015) (PubMed).

    Jiang, Li, Zhou, Wang, Zhang, Wang: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." in: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, (2014) (PubMed).

    Yan, Liang, Zhang, Liu, Bu: "Apoptotic induction of lung adenocarcinoma A549 cells infected by recombinant RVG Newcastle disease virus (rL-RVG) in vitro." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 317-26, (2014) (PubMed).

    Shan, Li, Newton, Zhao, Li, Guo: "A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells." in: Toxicology letters, Vol. 227, Issue 2, pp. 129-38, (2014) (PubMed).

    Xia, Luo, Lin, Zhang, Guo, He: "The effect of different treatment time of millimeter wave on chondrocyte apoptosis, caspase-3, caspase-8, and MMP-13 expression in rabbit surgically induced model of knee osteoarthritis." in: Rheumatology international, Vol. 32, Issue 9, pp. 2847-56, (2012) (PubMed).

    Lin, He, Luo, Zhang, Zeng: "The effect of low-level laser to apoptosis of chondrocyte and caspases expression, including caspase-8 and caspase-3 in rabbit surgery-induced model of knee osteoarthritis." in: Rheumatology international, Vol. 32, Issue 3, pp. 759-66, (2012) (PubMed).

    Zeng, Luo, Lin, Zhang, He: "The effect of therapeutic ultrasound to apoptosis of chondrocyte and caspase-3 and caspase-8 expression in rabbit surgery-induced model of knee osteoarthritis." in: Rheumatology international, Vol. 32, Issue 12, pp. 3771-7, (2012) (PubMed).

    Lian, Ni, Dai, Su, Smith, Xu, He: "Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation." in: Molecular cancer therapeutics, Vol. 11, Issue 2, pp. 416-26, (2012) (PubMed).

    Guo, Luo, Zhang, Lin, Xia, He: "Comparing different physical factors on serum TNF-? levels, chondrocyte apoptosis, caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits." in: Joint, bone, spine : revue du rhumatisme, Vol. 78, Issue 6, pp. 604-10, (2011) (PubMed).

  • Target
    Caspase 8 (CASP8)
    Alternative Name
    CASP8 (CASP8 Products)
    Synonyms
    casp8-A antibody, xCaspase-8 antibody, casp8 antibody, CASP8 antibody, CASP-8 antibody, FLICE antibody, MACH antibody, Mch5 antibody, ALPS2B antibody, CAP4 antibody, Casp-8 antibody, MCH5 antibody, caspase-8 antibody, zgc:92075 antibody, caspase 8 L homeolog antibody, death related ced-3/Nedd2-like protein antibody, caspase 8 antibody, caspase-8 antibody, caspase-8-like antibody, caspase 8, apoptosis-related cysteine peptidase antibody, casp8.L antibody, LOC661095 antibody, CASP8 antibody, LOC5563818 antibody, casp8 antibody, LOC100222284 antibody, Casp8 antibody
    Background
    CASP8 is also known as CAP4, MACH or MCH5. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

    Synonyms: ALPS2B antibody|Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody|Apoptosis related cysteine peptidase antibody|Apoptotic cysteine protease antibody|Apoptotic protease Mch 5 antibody|Apoptotic protease Mch-5 antibody|Apoptotic protease Mch5 antibody|CAP 4 antibody|CAP4 antibody|CASP 8 antibody|CASP-8 antibody|CASP8 antibody|CASP8_HUMAN antibody|Caspase 8 antibody|Caspase 8 apoptosis related cysteine peptidase antibody|Caspase-8 subunit p10 antibody|Caspase8 antibody|CED 3 antibody|FADD homologous ICE/CED 3 like protease antibody|FADD Homologous ICE/CED3 Like Protease antibody|FADD Like ICE antibody|FADD-homologous ICE/CED-3-like protease antibody|FADD-like ICE antibody|FLICE antibody|FLJ17672 antibody|ICE like apoptotic protease 5 antibody|ICE-like apoptotic protease 5 antibody|MACH alpha 1/2/3 protein antibody|MACH antibody|MACH beta 1/2/3/4 protein antibody|MCH 5 antibody|MCH5 antibody|MGC78473 antibody|MORT1 associated CED 3 homolog antibody|MORT1 associated CED3 homolog antibody|MORT1-associated CED-3 homolog antibody|OTTHUMP00000163717 antibody|OTTHUMP00000163720 antibody|OTTHUMP00000163724 antibody|OTTHUMP00000163725 antibody|OTTHUMP00000165062 antibody|OTTHUMP00000165063 antibody|OTTHUMP00000165064 antibody|OTTHUMP00000206552 antibody|OTTHUMP00000206582 antibody
    Gene ID
    12370
    UniProt
    O89110
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, TLR Signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
You are here:
Support