LTA antibody (Middle Region)

Catalog No. ABIN3042614

Product Details anti-LTA Antibody

Target: LTA (Lymphotoxin-alpha (LTA))

Binding Specificity: AA 73-88, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTA antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Lymphotoxin-alpha(LTA) detection. Tested with WB in Human.

Sequence: KQNSLLWRAN TDRAFL

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Lymphotoxin-alpha(LTA) detection. Tested with WB in Human.
Gene Name: lymphotoxin alpha(TNF superfamily, member 1)
Protein Name: Lymphotoxin-alpha(LT-alpha)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TNF beta(73-88aa KQNSLLWRANTDRAFL), different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for LTA

Target: LTA (Lymphotoxin-alpha (LTA))

Alternative Name: LTA (LTA Products)

Synonyms: LT antibody, TNFB antibody, TNFSF1 antibody, LT-[a] antibody, LT-alpha antibody, LT[a] antibody, LTalpha antibody, Ltx antibody, TNF-beta antibody, Tnfb antibody, Tnfsf1b antibody, hlb382 antibody, lymphotoxin alpha antibody, lymphotoxin A antibody, LTA antibody, Lta antibody

Target Type: Chemical

Background: Lymphotoxin(previously known as tumor necrosis factor-beta) is a lymphokine cytokine. It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them. Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs. Nedwin et al.(1985) found that TNFA and TNFB are closely linked on chromosome 6. Study of hybrid cells made with rearranged human chromosome 6 showed that both TNFA and TNFB map to the 6p23-q12 segment.

Synonyms: LTalpha antibody|DIF antibody|LT alpha antibody|LT antibody|LT-alpha antibody|LTA antibody|LTalpha antibody|Lymphotoxin alpha(TNF superfamily, member 1) antibody|Lymphotoxin alpha antibody|Lymphotoxin-alpha antibody|TNF B antibody|TNF superfamily member 1 antibody|TNF-beta antibody|TNFB antibody|TNFB_HUMAN antibody|TNFbeta antibody|TNFSF1 antibody|Tumor necrosis factor beta antibody|Tumor necrosis factor ligand superfamily member 1 antibody

UniProt: P01374

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process