CXCR1 antibody (N-Term)

Catalog No. ABIN3042912

Product Details anti-CXCR1 Antibody

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Binding Specificity: AA 24-38, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.

Sequence: DEDYSPCMLE TETLN

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for C-X-C chemokine receptor type 1(CXCR1) detection. Tested with WB, IHC-P in Human.
Gene Name: chemokine(C-X-C motif) receptor 1
Protein Name: C-X-C chemokine receptor type 1

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR1(24-38aa DEDYSPCMLETETLN).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CXCR1

Target: CXCR1 (Chemokine (C-X-C Motif) Receptor 1 (CXCR1))

Alternative Name: CXCR1 (CXCR1 Products)

Synonyms: C-C antibody, C-C-CKR-1 antibody, CD128 antibody, CD181 antibody, CDw128a antibody, CKR-1 antibody, CMKAR1 antibody, IL8R1 antibody, IL8RA antibody, IL8RBA antibody, Il8ra antibody, CXCR-1 antibody, IL-8RA antibody, CXCR2 antibody, IL8RB antibody, cxcr1 antibody, cxcr2 antibody, C-X-C motif chemokine receptor 1 antibody, chemokine (C-X-C motif) receptor 1 antibody, C-X-C chemokine receptor type 1 antibody, C-X-C motif chemokine receptor 1 S homeolog antibody, CXCR1 antibody, Cxcr1 antibody, LOC100461947 antibody, cxcr1.S antibody

Background: CXCR1(Chemokine,CXC Motif, Receptor 1), also known as IL8RA or IL8R1, is a chemokine receptor. IL8RA is its human gene. Morris et al.(1992) mapped the IL8RA gene to chromosome 2q35. Hartl et al.(2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA(GRO) with a low affinity.

Synonyms: C C antibody|C C CKR 1 antibody|C-X-C chemokine receptor type 1 antibody|CCCKR1 antibody|CD 181 antibody|CD128 antibody|CD181 antibody|CD181 antigen antibody|CDw128a antibody|Chemokine(C X C motif) receptor 1 antibody|Chemokine(C X C) receptor 1 antibody|Chemokine receptor 1 antibody|CKR 1 antibody|CMKAR1 antibody|CXC-R1 antibody|CXCR 1 antibody|CXCR-1 antibody|CXCR1 antibody|CXCR1_HUMAN antibody|High affinity interleukin 8 receptor A antibody|High affinity interleukin-8 receptor A antibody|IL 8 receptor type 1 antibody|IL 8R A antibody|IL-8 receptor type 1 antibody|IL-8R A antibody|IL8 receptor antibody|IL8 receptor type 1 antibody|IL8R1 antibody|IL8RA antibody|IL8RBA antibody|Interleukin 8 receptor alpha antibody|Interleukin 8 receptor type 1 antibody|Interleukin 8 receptor type A antibody

UniProt: P25024

Pathways: cAMP Metabolic Process