TXNRD2 antibody (C-Term)

Catalog No. ABIN3043001

Product Details anti-TXNRD2 Antibody

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Binding Specificity: AA 418-434, C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Thioredoxin reductase 2, mitochondrial(TXNRD2) detection. Tested with WB, IHC-P in Human,Rat.

Sequence: RHGQEHVEVY HAHYKPL

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Thioredoxin reductase 2, mitochondrial(TXNRD2) detection. Tested with WB, IHC-P in Human,Rat.
Gene Name: thioredoxin reductase 2
Protein Name: Thioredoxin reductase 2, mitochondrial

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human TXNRD2(418-434aa RHGQEHVEVYHAHYKPL), different from the related rat sequence by three amino acids, and from the related mouse sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TXNRD2

Target: TXNRD2 (Thioredoxin Reductase 2 (TXNRD2))

Alternative Name: TXNRD2 (TXNRD2 Products)

Synonyms: CG11401 antibody, Dm-TrxR antibody, DmTrx antibody, DmTrxR-2 antibody, Dmel\\CG11401 antibody, Trxr2 antibody, trxr-2 antibody, SELZ antibody, TR antibody, TR-BETA antibody, TR3 antibody, TRXR2 antibody, AA118373 antibody, ESTM573010 antibody, TGR antibody, Tr3 antibody, Trxrd2 antibody, thioredoxin reductase 2 antibody, Trxr-2 antibody, TXNRD2 antibody, Txnrd2 antibody

Background: TXNRD2(Thioredoxin reductase 2), also known as TRXR2, TR3, SELZ, or TR-BETA, Thioredoxin reductases, are selenocysteine(sec)-containing flavoenzymes that maintain thioredoxins, small proteins that catalyze redox reactions, in the reduced state using the reducing power of NADPH. By STS analysis and genomic sequence analysis, respectively, Miranda-Vizuete et al.(1999) and Sun et al.(1999) mapped the TXNRD2 gene to chromosome 22q11.2. Miranda-Vizuete et al.(1999) mapped the mouse gene to chromosome 16. Gasdaska et al.(1999) showed that TXNRD2 was a thioredoxin reductase that could directly reduce proteins such as insulin.

Synonyms: mitochondrial antibody|selenoprotein Z antibody|SELZ antibody|Thioredoxin reductase 2 antibody|Thioredoxin reductase 2 mitochondrial antibody|thioredoxin reductase 3 antibody|thioredoxin reductase beta antibody|Thioredoxin reductase TR3 antibody|TR 3 antibody|TR antibody|TR beta antibody|TR-beta antibody|TR3 antibody|TRXR 2 antibody|TRXR2 antibody|TRXR2_HUMAN antibody|TXNRD 2 antibody|Txnrd2 antibody

Pathways: Cell RedoxHomeostasis