TFPI antibody (N-Term)

Catalog No. ABIN3043049

Product Details anti-TFPI Antibody

Target: TFPI (Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI))

Binding Specificity: AA 261-280, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFPI antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Tissue factor pathway inhibitor(TFPI) detection. Tested with WB, IHC-P in Human.

Sequence: QECLRACKKG FIQRISKGGL

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Tissue factor pathway inhibitor(TFPI) detection. Tested with WB, IHC-P in Human.
Gene Name: tissue factor pathway inhibitor(lipoprotein-associated coagulation inhibitor)
Protein Name: Tissue factor pathway inhibitor

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TFPI(261-280aa QECLRACKKGFIQRISKGGL).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TFPI

Target: TFPI (Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor) (TFPI))

Alternative Name: TFPI (TFPI Products)

Synonyms: EPI antibody, LACI antibody, TFI antibody, TFPI1 antibody, A630013F22Rik antibody, AW552122 antibody, TFPI antibody, si:dz44f8.1 antibody, tfpib antibody, wu:fb92g01 antibody, zgc:152844 antibody, zgc:158592 antibody, tissue factor pathway inhibitor antibody, tissue factor pathway inhibitor a antibody, TFPI antibody, Tfpi antibody, tfpia antibody

Background: TFPI(Tissue factor pathway inhibitor) also known as EPI, LACI, TFI and TFPT1 is a single-chain polypeptide which can reversibly inhibit Factor Xa(Xa) and Thrombin(Factor IIa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM. The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70 kb. TFPI has a relative molecular mass of 34,000 to 40,000 depending on the degree of proteolysis of the C-terminal region.

Synonyms: Anti convertin antibody|EPI antibody|Extrinsic pathway inhibitor antibody|LACI antibody|Lipoprotein associated coagulation inhibitor antibody|Lipoprotein-associated coagulation inhibitor antibody|TFI antibody|TFPI 1 antibody|TFPI antibody|TFPI1 antibody|TFPI1_HUMAN antibody|Tissue factor pathway inhibitor(lipoprotein associated coagulation inhibitor) antibody|Tissue factor pathway inhibitor antibody

UniProt: P10646