KCNA5 antibody (C-Term)

Catalog No. ABIN3043267

Product Details anti-KCNA5 Antibody

Target: KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))

Binding Specificity: AA 583-613, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNA5 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily A member 5(KCNA5) detection. Tested with WB in Human.

Sequence: LEKCNVKAKS NVDLRRSLYA LCLDTSRETD L

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily A member 5(KCNA5) detection. Tested with WB in Human.
Gene Name: potassium channel, voltage gated shaker related subfamily A, member 5
Protein Name: Potassium voltage-gated channel subfamily A member 5

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA5 (583-613aa LEKCNVKAKSNVDLRRSLYALCLDTSRETDL), different from the related mouse and rat sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for KCNA5

Target: KCNA5 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 5 (KCNA5))

Alternative Name: KCNA5 (KCNA5 Products)

Synonyms: KCNA5 antibody, kcna5 antibody, ATFB7 antibody, HCK1 antibody, HK2 antibody, HPCN1 antibody, KV1.5 antibody, PCN1 antibody, Kv1.5 antibody, Kv1 antibody, potassium voltage-gated channel subfamily A member 5 antibody, potassium channel, voltage gated shaker related subfamily A, member 5 antibody, potassium voltage-gated channel, shaker-related subfamily, member 5 antibody, KCNA5 antibody, kcna5 antibody, Kcna5 antibody

Background: Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Synonyms: ATFB7 antibody|cardiac potassium channel antibody|HCK1 antibody|HK2 antibody|HPCN1 antibody|insulinoma and islet potassium channel antibody|KCNA5 antibody|KCNA5_HUMAN antibody|Kv1 antibody|KV1.5 antibody|MGC117058 antibody|MGC117059 antibody|MGC25248 antibody|PCN1 antibody|Potassium channel 1 antibody|Potassium channel insulinoma and islet cell antibody|Potassium channel, insulinoma and islet cell antibody|Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody|Potassium voltage gated channel shaker related subfamily member 5 antibody|Potassium voltage gated channel subfamily A member 5 antibody|Potassium voltage-gated channel subfamily A member 5 antibody|Voltage-gated potassium channel HK2 antibody|voltage-gated potassium channel protein Kv1.5 antibody| Voltage-gated potassium channel subunit Kv1.5 antibody

Gene ID: 3741

UniProt: P22460