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RASA1 antibody (C-Term)

RASA1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043368
  • Target See all RASA1 Antibodies
    RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
    Binding Specificity
    • 15
    • 15
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1018-1047, C-Term
    Reactivity
    • 48
    • 29
    • 28
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 71
    • 7
    • 1
    Rabbit
    Clonality
    • 73
    • 6
    Polyclonal
    Conjugate
    • 31
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RASA1 antibody is un-conjugated
    Application
    • 36
    • 32
    • 26
    • 26
    • 9
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Ras GTPase-activating protein 1(RASA1) detection. Tested with WB in Human.
    Sequence
    AQQHVLKKLL AITELLQQKQ NQYTKTNDVR
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Ras GTPase-activating protein 1(RASA1) detection. Tested with WB in Human.
    Gene Name: RAS p21 protein activator (GTPase activating protein) 1
    Protein Name: Ras GTPase-activating protein 1
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human RASA1 (1018-1047aa AQQHVLKKLLAITELLQQKQNQYTKTNDVR), different from the related rat sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product RASA1 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    RASA1 (RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
    Alternative Name
    RASA1 (RASA1 Products)
    Synonyms
    CG9209 antibody, D-RasGAP antibody, Dmel\\CG9209 antibody, RAS-GAP antibody, RasGAP antibody, RasGap antibody, rasGap antibody, CM-AVM antibody, CMAVM antibody, GAP antibody, PKWS antibody, RASA antibody, RASGAP antibody, p120GAP antibody, p120RASGAP antibody, GAPX antibody, Rasa antibody, Gap antibody, vacuolar peduncle antibody, RAS p21 protein activator 1 antibody, vap antibody, RASA1 antibody, Rasa1 antibody
    Background
    RASA1, also known as RAS p21 protein activator 1, is a 120- kDacytosolic human protein. The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

    Synonyms: CM AVM antibody|CMAVM antibody|DKFZp434N071 antibody|GAP antibody|GTPase activating protein antibody|GTPase-activating protein antibody|OTTHUMP00000222390 antibody|OTTHUMP00000222391 antibody|OTTHUMP00000222392 antibody|OTTHUMP00000222393 antibody|p120GAP antibody|p120RASGAP antibody|PKWS antibody|Ras GTPase-activating protein 1 antibody|RAS p21 protein activator (GTPase activating protein) 1 antibody|Ras p21 protein activator antibody|RASA antibody|RASA1 antibody|RASA1_HUMAN antibody|RasGAP antibody| Triphosphatase activating protein antibody
    Gene ID
    5921
    UniProt
    P20936
    Pathways
    Regulation of Actin Filament Polymerization, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals
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