CCL5 antibody (AA 26-91)

Catalog No. ABIN3043478

Product Details anti-CCL5 Antibody

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Binding Specificity: AA 26-91

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Rabbit IgG polyclonal antibody for C-C motif chemokine 5(CCL5) detection. Tested with WB, ELISA in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for C-C motif chemokine 5(CCL5) detection. Tested with WB, ELISA in Human.
Gene Name: chemokine (C-C motif) ligand 5
Protein Name: C-C motif chemokine 5

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human RANTES recombinant protein (Position: Y26-S91). Human RANTES shares 83.3% amino acid (aa) sequence identity with both mouse and rat RANTES.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

References for anti-CCL5 antibody (ABIN3043478)

Wei, Feng, Sun, Cheng, Ma, Zhao, Dong, Zhang, Li: "Different locations of RANTES and its receptors on mouse epididymal spermatozoa." in: Reproduction, fertility, and development, (2015) (PubMed).

Li, Sun, Liao, Ma, Ma, Zhang: "Regulated upon activation normal T-cell expressed and secreted originating from the epididymis differentially associates with viable and defective spermatozoa." in: Fertility and sterility, Vol. 93, Issue 8, pp. 2661-7, (2010) (PubMed).

Target Details for CCL5

Target: CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))

Alternative Name: CCL5 (CCL5 Products)

Synonyms: Rantes antibody, Scya5 antibody, D17S136E antibody, RANTES antibody, SCYA5 antibody, SIS-delta antibody, SISd antibody, TCP228 antibody, eoCP antibody, MuRantes antibody, C-C motif chemokine 5-like antibody, C-C motif chemokine ligand 5 antibody, chemokine (C-C motif) ligand 5 antibody, LOC100230935 antibody, CCL5 antibody, Ccl5 antibody

Background: Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. It is also known as RANTES. This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.

Synonyms: Beta chemokine RANTES precursor antibody|CCL 5 antibody|CCL5 antibody|CCL5_HUMAN antibody|Chemokine (C C motif) ligand 5 antibody| Chemokine CC Motif Ligand 5 antibody|D17S136E antibody|EoCP antibody|Eosinophil chemotactic cytokine antibody|MGC17164 antibody| RANTES(4-68) antibody|Regulated upon activation normally T expressed and presumably secreted antibody|SCYA 5 antibody|SCYA5 antibody| SIS delta antibody|SIS-delta antibody|SISd antibody|Small inducible cytokine A5 (RANTES) antibody|Small inducible cytokine A5 antibody|Small inducible cytokine subfamily A (Cys Cys) member 5 antibody|Small-inducible cytokine A5 antibody|T cell specific protein p288 antibody|T cell specific RANTES protein antibody|T cell-specific protein P228 antibody|T-cell-specific protein RANTES antibody| TCP 228 antibody|TCP228 antibody

Gene ID: 6352

UniProt: P13501

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration