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ERBB4 antibody (N-Term)

ERBB4 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044100
  • Target See all ERBB4 Antibodies
    ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
    Binding Specificity
    • 30
    • 25
    • 25
    • 19
    • 15
    • 15
    • 15
    • 9
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 35-51, N-Term
    Reactivity
    • 172
    • 98
    • 59
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 198
    • 22
    Rabbit
    Clonality
    • 195
    • 25
    Polyclonal
    Conjugate
    • 73
    • 18
    • 16
    • 14
    • 11
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    This ERBB4 antibody is un-conjugated
    Application
    • 112
    • 95
    • 67
    • 67
    • 66
    • 32
    • 22
    • 17
    • 17
    • 10
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    KLSSLSDLEQ QYRALRK
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian)
    Protein Name: Receptor tyrosine-protein kinase erbB-4
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.
    Isotype
    IgG
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for ERBB4 is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Target
    ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
    Alternative Name
    ERBB4 (ERBB4 Products)
    Synonyms
    erbb4 antibody, si:ch211-227n20.1 antibody, Her4 antibody, c-erbB-4 antibody, HER4 antibody, p180erbB4 antibody, erb-b2 receptor tyrosine kinase 4 antibody, erb-b2 receptor tyrosine kinase 4a antibody, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody, erb-b2 receptor tyrosine kinase 4 L homeolog antibody, receptor tyrosine-protein kinase ErbB-4 antibody, ERBB4 antibody, erbb4a antibody, erbb4 antibody, erbb4.L antibody, Tsp_13582 antibody, Erbb4 antibody
    Background
    ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.

    Synonyms: 4ICD antibody|Avian erythroblastic leukemia viral oncogene homolog 4 antibody|Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody|E4ICD antibody|EC 2.7.10.1 antibody|ErbB4 antibody|ERBB4 intracellular domain antibody|ERBB4_HUMAN antibody|HER 4 antibody|HER4 antibody|Mer4 antibody|MGC138404 antibody|Oncogene ERBB4 antibody|P180erbB4 antibody|Proto-oncogene-like protein c-ErbB-4 antibody|Receptor protein tyrosine kinase erbB 4 precursor antibody|Receptor tyrosine protein kinase erbB 4 antibody|s80HER4 antibody|Tyrosine kinase type cell surface receptor HER4 antibody|Tyrosine kinase-type cell surface receptor HER4 antibody|v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody|v erb a erythroblastic leukemia viral oncogene homolog 4 antibody|v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody|V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody|Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody|Verba erythroblastic leukemia viral oncogene homolog 4 antibody|VERBB2 antibody
    UniProt
    Q15303
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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