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NRP2 antibody (N-Term)

NRP2 Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044160
  • Target See all NRP2 Antibodies
    NRP2 (Neuropilin 2 (NRP2))
    Binding Specificity
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 45-60, N-Term
    Reactivity
    • 46
    • 24
    • 19
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Host
    • 50
    • 3
    Rabbit
    Clonality
    • 51
    • 2
    Polyclonal
    Conjugate
    • 26
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NRP2 antibody is un-conjugated
    Application
    • 39
    • 23
    • 11
    • 5
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Neuropilin-2(NRP2) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    YPQDYPSHQN CEWIVY
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: human, mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for Neuropilin-2(NRP2) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: neuropilin 2
    Protein Name: Neuropilin-2
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human NRP2(45-60aa YPQDYPSHQNCEWIVY), identical to the related mouse sequence and different from the related rat sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product NRP2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Target
    NRP2 (Neuropilin 2 (NRP2))
    Alternative Name
    NRP2 (NRP2 Products)
    Synonyms
    NP2 antibody, NPN2 antibody, PRO2714 antibody, VEGF165R2 antibody, 1110048P06Rik antibody, Np-2 antibody, Np2 antibody, Npn-2 antibody, Npn2 antibody, neuropilin-2 antibody, neuropilin 2 antibody, NRP2 antibody, Nrp2 antibody
    Background
    NRP2(Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped on 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. Sema3b can act to repulse axons expressing neuropilin-2 and can antagonize the repulsive action of Sema3a on axonal growth cones expressing neuropilin-1. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3(PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in Npn2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of Npn2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

    Synonyms: MGC126574 antibody|Neuropilin 2 antibody|Neuropilin-2 antibody|Neuropilin2 antibody|NP 2 antibody|NP2 antibody|NPN 2 antibody|NPN2 antibody|NRP 2 antibody|Nrp2 antibody|NRP2_HUMAN antibody|PRO2714 antibody|Receptor for VEGF165 and semaphorins class3 antibody|Vascular endothelial cell growth factor 165 receptor 2 antibody|Vascular endothelial growth factor 165 receptor 2 antibody|VEGF1265R2 antibody|VEGF165R2 antibody
    UniProt
    O60462
    Pathways
    Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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