Synaptosomal-Associated Protein, 23kDa (SNAP23) (AA 192-211), (C-Term) antibody

Details for Product No. ABIN3044163, Supplier: Log in to see
Antigen
  • 23kDa
  • AA408749
  • SNAP-23
  • Sndt
  • Syndet
  • HsT17016
  • SNAP23A
  • SNAP23B
  • XOSNAP-23
  • snap23-A
  • synaptosomal-associated protein, 23kDa
  • synaptosomal-associated protein 23
  • SNAP23
  • snap23
  • Snap23
Epitope
AA 192-211, C-Term
25
14
10
6
5
4
4
3
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
118
34
34
6
4
4
1
1
1
1
1
1
Host
Rabbit
73
32
14
1
1
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
96
56
41
25
13
13
9
8
3
3
Options
Supplier
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Purpose Rabbit IgG polyclonal antibody for Synaptosomal-associated protein 23(SNAP23) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP23(192-211aa DTNRDRIDIANARAKKLIDS), different from the related rat and mouse sequences by three amino acids.
Sequence DTNRDRIDIA NARAKKLIDS
Isotype IgG
Cross-Reactivity (Details) No cross reactivity with other proteins.
Characteristics Rabbit IgG polyclonal antibody for Synaptosomal-associated protein 23(SNAP23) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: synaptosomal-associated protein, 23 kDa
Protein Name: Synaptosomal-associated protein 23(SNAP-23)
Purification Immunogen affinity purified.
Alternative Name SNAP23 (SNAP23 Antibody Abstract)
Background SNAP23(Synaptosomal-Associated Protein, 23-KD), also called SNAP23A, is a protein that in humans is encoded by the SNAP23 gene. The SNAP23 gene has 8 exons, with the initiation codon located in exon 2. The SNAP23 gene is mapped on 15q15.1-q15.2. The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23 kD. Its amino acid sequence is 59 % identical to that of SNAP25. Northern blot analysis revealed that SNAP23 is ubiquitously expressed. SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins. After relocation, SNAP23 is required for exocytosis, implying a crucial role in promoting membrane fusion. TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells. STX3A and SNAP23 were codistributed at the apical plasma membrane, where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.

Synonyms: HsT17016 antibody|LS-B8340 antibody|SNAP 23 antibody|SNAP-23 antibody|SNAP23 antibody|SNAP23A antibody|SNAP23B antibody|SNP23_HUMAN antibody|Synaptosomal associated protein 23 antibody|Synaptosomal associated protein 23 kDa antibody|Synaptosomal associated protein antibody|Synaptosomal-associated protein 23 antibody|Vesicle membrane fusion protein SNAP 23 antibody|Vesicle membrane fusion protein SNAP23 antibody|Vesicle-membrane fusion protein SNAP-23 antibody
UniProt O00161
Research Area Neurology
Application Notes WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Predicted Species: Rat
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Comment

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Preservative Thimerosal (Merthiolate), Sodium azide
Precaution of Use This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Synaptosomal-Associated Protein, 23kDa (SNAP23) (AA 192-211), (C-Term) antibody (ABIN3044163) Anti-SNAP23 antibody,ICC ICC: K562 Cell
Western Blotting (WB) image for anti-Synaptosomal-Associated Protein, 23kDa (SNAP23) (AA 192-211), (C-Term) antibody (ABIN3044163) Anti-SNAP23 antibody, Western blotting Lane 1: Rat Spleen Tissue Lysate Lane 2: Rat t...
Immunohistochemistry (IHC) image for anti-Synaptosomal-Associated Protein, 23kDa (SNAP23) (AA 192-211), (C-Term) antibody (ABIN3044163) Anti-SNAP23 antibody, IHC(P) IHC(P): Human Placenta Tissue
Immunohistochemistry (IHC) image for anti-Synaptosomal-Associated Protein, 23kDa (SNAP23) (AA 192-211), (C-Term) antibody (ABIN3044163) Anti-SNAP23 antibody, IHC(F) IHC(F): Human Placenta Tissue
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