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Neuregulin 2 antibody (Middle Region)

NRG2 Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044233
  • Target See all Neuregulin 2 (NRG2) Antibodies
    Neuregulin 2 (NRG2)
    Binding Specificity
    • 12
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 289-306, Middle Region
    Reactivity
    • 36
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 36
    • 4
    Rabbit
    Clonality
    • 37
    • 3
    Polyclonal
    Conjugate
    • 17
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Neuregulin 2 antibody is un-conjugated
    Application
    • 23
    • 23
    • 16
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for Pro-neuregulin-2, membrane-bound isoform(NRG2) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    NGRKNSRLQF NKVKVEDA
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for Pro-neuregulin-2, membrane-bound isoform(NRG2) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: neuregulin 2
    Protein Name: Pro-neuregulin-2, membrane-bound isoform(Pro-NRG2)
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human NRG2(289-306aa NGRKNSRLQFNKVKVEDA), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product NRG2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Target
    Neuregulin 2 (NRG2)
    Alternative Name
    NRG2 (NRG2 Products)
    Synonyms
    NRG2 antibody, Don1 antibody, NTAK antibody, DON1 antibody, HRG2 antibody, NTAK_alpha2a antibody, Ntak antibody, neuregulin 2 antibody, NRG2 antibody, Nrg2 antibody
    Background
    Neuregulin 2, also known as NRG2, DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2(NRG2) is a novel member of the neuregulin family of growth and differentiation factors. The NRG2 gene is mapped to 5q31.2. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human NRG2 gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The NRG2 genomic structure is similar to that of neuregulin 1(NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

    Synonyms: Divergent of neuregulin 1 antibody|Divergent of neuregulin-1 antibody|Don 1 antibody|DON-1 antibody|Neural- and thymus-derived activator for ERBB kinases antibody|Neuregulin 2 antibody|Neuregulin-2 antibody|NRG-2 antibody|Nrg2 antibody|NRG2_HUMAN antibody|NTAK antibody|Pro NRG2 antibody|Pro-NRG2 antibody
    UniProt
    O14511
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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