Serotonin Receptor 1A antibody (C-Term)

Catalog No. ABIN3044241

Product Details anti-Serotonin Receptor 1A Antibody

Target: Serotonin Receptor 1A (HTR1A)

Binding Specificity: AA 404-422, C-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: NKDFQNAFKK IIKCKFCRQ

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: 5-hydroxytryptamine(serotonin) receptor 1A, G protein-coupled
Protein Name: 5-hydroxytryptamine receptor 1A(5-HT-1A/5-HT1A)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Rat, Predicted Species: Human, Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: HTR1A (HTR1A Products)

Synonyms: 5-HT-dro2A antibody, 5-HT1ADro antibody, 5-HT[1A]Dro antibody, 5-HT[[1ADro]] antibody, 5-HT[[1A]] antibody, 5-HT[[1A]]DRO antibody, 5HT-R2A antibody, 5HT-dro2A antibody, 5HT-drp[[2A]] antibody, 5HT1A antibody, 5HT[[1ADro]] antibody, 5htdro2a antibody, CG16720 antibody, DRO2A antibody, Dm5HTdro2A antibody, Dmel\\CG16720 antibody, d5-HT1A antibody, 5htr1a antibody, htr1a antibody, HTR1A antibody, Htr1a antibody, 5-Ht1a antibody, Gpcr18 antibody, 5-HT-1A antibody, 5-HT1A antibody, 5HT1a antibody, ADRB2RL1 antibody, ADRBRL1 antibody, G-21 antibody, PFMCD antibody, RAT5HT1A antibody, 5ht1a antibody, adrb2rl1 antibody, adrbrl1 antibody, htr1a-A antibody, 5-hydroxytryptamine (serotonin) receptor 1A antibody, 5-hydroxytryptamine receptor 1A antibody, 5-hydroxytryptamine (serotonin) receptor 1A a antibody, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog antibody, 5-HT1A antibody, HTR1A antibody, htr1aa antibody, Htr1a antibody, htr1a.L antibody

Background: HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

Synonyms: 5 HT 1A antibody|5 HT receptor 1A antibody|5 HT1A antibody|5 HT1A receptor antibody|5 hydroxytryptamine(serotonin) receptor 1A antibody|5 hydroxytryptamine(serotonin) receptor 1A G protein coupled antibody|5 hydroxytryptamine receptor 1A antibody|5-HT-1A antibody|5-HT1A antibody|5-hydroxytryptamine receptor 1A antibody|5HT 1A antibody|5HT 1A receptor antibody|5HT receptor 1A antibody|5HT1a antibody|5HT1A_HUMAN antibody|ADRB2RL1 antibody|ADRBRL1 antibody|G 21 antibody|G protein coupled receptor antibody|G-21 antibody|Gpcr 18 antibody|Gpcr18 antibody|Guanine nucleotide binding regulatory protein-coupled receptor antibody|HTR1A antibody|PFMCD antibody|Serotonin 1A receptor antibody|Serotonin 5HT1A receptor antibody|Serotonin receptor 1A antibody

UniProt: P08908

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour