MMP24 antibody (N-Term)

Catalog No. ABIN3044304

Product Details anti-MMP24 Antibody

Target: MMP24 (Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24))

Binding Specificity: AA 208-225, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP24 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Matrix metalloproteinase-24(MMP24) detection. Tested with WB in Human,Mouse,Rat.

Sequence: YHEIKSDRKE ADIMIFFA

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Matrix metalloproteinase-24(MMP24) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: matrix metallopeptidase 24(membrane-inserted)
Protein Name: Matrix metalloproteinase-24

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human MMP24(208-225aa YHEIKSDRKEADIMIFFA), identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

References for anti-MMP24 antibody (ABIN3044304)

Liu, Liu, Tan, Tang, Long, Li, Liang, Chu, Yang: "Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8953-8963, (2018) (PubMed).

Li, Li, Zeng, Liu, Yang: "H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-β1 expression." in: Renal failure, Vol. 39, Issue 1, pp. 265-272, (2017) (PubMed).

Target Details for MMP24

Target: MMP24 (Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24))

Alternative Name: MMP24 (MMP24 Products)

Synonyms: MMP-24 antibody, MMP25 antibody, MT-MMP 5 antibody, MT-MMP5 antibody, MT5-MMP antibody, MT5MMP antibody, MTMMP5 antibody, AU040325 antibody, Mt5-mmp antibody, si:ch211-239j9.5 antibody, MMP24 antibody, mt3-mmp antibody, matrix metallopeptidase 24 antibody, matrix metallopeptidase 16 S homeolog antibody, MMP24 antibody, Mmp24 antibody, mmp24 antibody, mmp16.S antibody

Background: Matrix metalloproteinase-24, also known as MT5MMP or MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase(MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP(MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.

Synonyms: Matrix metallopeptidase 24(membrane inserted) antibody|Matrix metallopeptidase 24 antibody|Membrane type 5 matrix metalloproteinase antibody|Membrane type matrix metalloproteinase 5 antibody|Membrane-type matrix metalloproteinase 5 antibody|Membrane-type-5 matrix metalloproteinase antibody|MMP 24 antibody|MMP 25 antibody|MMP-24 antibody|Mmp24 antibody|MMP24_HUMAN antibody|MMP25 antibody|MT MMP5 antibody|MT-MMP 5 antibody|MT5 MMP antibody|MT5-MMP antibody|MT5MMP antibody|MTMMP5 antibody|Processed matrix metalloproteinase-24 antibody

UniProt: Q9Y5R2