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Description
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Gene: IL8 / IL-8, Standard Gene Symbol: IL8, Family: Intercrine, Subfamily: Intercrine alpha, Synonyms: IL8, CXCL8, Emoctakin, GCP-1, GCP1, Granulocyte chemotactic protein 1, IL-8, Interleukin-8, LECT, LUCT, Lymphocyte-derived neutrophil- activating factor, LYNAP, MDNCF, MONAP, Monocyte-derived neutrophil chemotactic factor, NAF, NAP-1, NAP1, Neutrophil- activating protein 1, Neutrophil-activating factor, Protein 3-10c, SCYB8, T-cell chemotactic factor
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Specificity
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Specific for human IL-8 (interleukin-8), a pro-inflammatory CXC chemokine designated CXCL8, secreted by endothelial cells and monocytes, which acts as a major chemoattractant for neutrophils, T cells and basophils. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumors. Previous nomenclature for IL-8 includes neutrophil activating protein 1(NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C
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