tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide (YWHAQ) antibody

Antigen: tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, theta Polypeptide (YWHAQ)

Synonyms: HS1, GW128, KCIP-1, 1C5, 14-3-3, R74690, AA409740, AU021156, MGC118161, 2700028P07Rik, 14-3-3t, MGC53015, 1c5, hs1, MGC69491, YWHAQ, MGC127486, DKFZp459M2030

Clonality: Monoclonal (3B9)

Host: Mouse

Reactivity: Human, Mouse (Murine), Rat (Rattus), Cow (Bovine)

Application: Western Blotting (WB)

Catalog no.: ABIN306690

Additional Information

Alternative name: 14-3-3 theta/tau

Swiss-Prot: P27348

Isotype: IgG1  (Matching secondary antibodies)

Clone: 3B9

Description: At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases. Synonyms: mouse anti 14-3-3 theta/tau, theta tau.

Application Details

Application Notes: Clone 3B9 anti-14-3-3 / reacts specifically with the / isoform and does not react with 14-3-3 .. Positive Control: 3T3, PC12, Jurkat.

Concentration: 1 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only