ADAM Metallopeptidase Domain 10 (ADAM10) (C-Term) antibody

Antigen: ADAM Metallopeptidase Domain 10 (ADAM10)

Synonyms: kuz, AD10, MADM, CD156c, HsT18717, kuzbanian, 1700031C13Rik, ADAM10, adam10, wu:fc03d12, ADAM-10, DKFZp459A157, LOC100219653, Adam10

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN306736

Additional Information

Alternative name: ADAM 10 (CT) (kuz) (TNFa converting enzyme)

Swiss-Prot: O14672

Isotype: IgG  (Matching secondary antibodies)

Description: Proinflammatory cytokine tumor necrosis factor- (TNF- ) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF- , notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF- , notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4). Synonyms: KUZ, MADM.

Application Details

Application Notes: Detects ADAM10 by Western blot at 0.25 to 1 ug/ml. Detects an 85 kDa band can be detected in Jurkat cell lysates which may represent precursor protein. A faint 60 kDa band is also detected in some cell lines, including Jurkat, which may be processed mature protein. Positive Control: Jurkat whole cell lysate.

Concentration: 0.5 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only