Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B) (C-Term) antibody

Antigen: Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B)

Synonyms: DTL, BAFF, BLYS, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNFSF13B, RGD1561519

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN306751

Additional Information

Alternative name: Tumor necrosis factor ligand superfamily member 13B (C Terminal)

Swiss-Prot: Q9Y275

Isotype: IgG

Description: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF- B and c-jun N-terminal Kinase) (1-4). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion (1,2). Two receptors for BAFF were recently identified and designated TACI and BCMA (5). BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases (5,6). Like TNF and TRAIL, THANK was shown to activate NF- B and c-jun N-terminal kinase (JNK) and to induce apoptosis (4). Synonyms: BAFF, BLYS, TALL1, TNFSF20, ZTNF4.

Application Details

Application Notes: Detects BAFF by Western blot at 0.25 to 1 ug/ml. Positive Control: HL60 cell lysate and mouse spleen tissue lysate.

Concentration: 0.5 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only