BCL2-Associated Athanogene 4 (BAG4) (N-Term) antibody

Antigen: BCL2-Associated Athanogene 4 (BAG4)

Synonyms: SODD, BAG-4, Bag4, BAG4, fd20a04, wu:fd20a04, si:dkey-220o5.3

Epitope: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Application: Western Blotting (WB)

Catalog no.: ABIN306752

Additional Information

Alternative name: BAG-4 (NT)/ SODD (NT )(Silencer of Death Domains)

Swiss-Prot: O95429

Isotype: IgG  (Matching secondary antibodies)

Description: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains (1). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines. Synonyms: BAG4, SODD.

Application Details

Application Notes: Detects SODD by Western blot at 0.25 to 1 ug/ml. Detects an approximately 60 kDa band in HeLa and THP-1 whole cell lysate. Positive Control: HeLa and THP-1 whole cell lysate.

Concentration: 0.5 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only