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beta-Site APP-Cleaving Enzyme 1 (BACE) (C-Term) antibody
| Antigen | beta-Site APP-Cleaving Enzyme 1 (BACE) |
| Synonyms |
ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, M ...
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| Epitope |
 Alternatives C-Term |
| Clonality | Polyclonal |
| Host |
Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine) |
| Application |
Alternatives Western Blotting (WB)
|
| Catalog no. | ABIN306765 |
| Quantity | 100 ug (0.5 mg/ml) |
| Price | 245.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | Beta-secretase 1 (CT) |
| Swiss-Prot | P56817 |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Accumulation of the amyloid- (A ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A peptide is generated by proteolytic cleavage of the amyloid protein precursor (APP) at - and -sites by two proteases. APP is first cleaved by secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for secretase to generate the 4 kDa amyloid- peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP. Synonyms: BACE, KIAA1149, Beta-site amyloid precursor protein cleaving enzyme 1. |
| Synonyms | ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2 |
Application Details
| Application Notes | Detects BACE by Western blot at 0.5 to 1 ug/ml. Detects an approximately 70 kDa band in human brain tissue lysate. Positive Control: Human brain tissue lysate. |
| Concentration | 0.5 mg/ml |
| Storage | Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "beta-Site APP-Cleaving Enzyme 1 (BACE)", type "Antibodies"
| Hosts | Rabbit (51), Mouse (6), Goat (2) |
| Reactivities | Human (51), Mouse (Murine) (21), Rat (Rattus) (7), Cow (Bovine) (1), Horse (Equine) (1), Pig (Porcine) (1), Rabbit (1) |
| Applications | Western Blotting (WB) (44), ELISA (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17), Enzyme Immunoassay (EIA) (12), Flow Cytometry (FACS) (9), Immunohistochemistry (IHC) (7), Immunofluorescence (IF) (6), Immunoprecipitation (IP) (5), ELISA (Detection) (1), Immunocytochemistry (ICC) (1), Neutralization (Neut) (1) |
| Conjugates | APC (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), PE,Cy5.5 (1) |
| Epitopes | N-Term (3), pSer498 (3), AA 26-45 (2), AA 46-65 (2), AA 485-501 (2), C-Term (2), S498 (1), pS498 (1) |
