beta-Site APP-Cleaving Enzyme 2 (BACE2) (C-Term) antibody

Antigen: beta-Site APP-Cleaving Enzyme 2 (BACE2)

Synonyms: ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN306767

Additional Information

Alternative name: Beta-secretase 2 (CT)

Swiss-Prot: Q9Y5Z0

Isotype: IgG  (Matching secondary antibodies)

Description: Accumulation of the amyloid- (A ) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A peptide is generated by proteolytic cleavage of the amyloid protein precursor (APP) at - and -sites by proteases. The long-sought secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2)1-4. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 14-9. BACE2 also cleaves APP at -site and at a different site within A 8. BACE2 locates on chromosome 21q22.3, the so-called

Application Details

Application Notes: Detects BACE2 by Western blot at 0.5 to 1 ug/ml. Detects an approximately 70 kDa band in human heart tissue lysate. Positive Control: Human heart tissue lysate.

Concentration: 0.5 mg/ml

Storage: Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Restrictions: For Research Use only