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MAPT antibody (Microtubule-Associated Protein tau) (pan)

Details for Product anti-MAPT Antibody No. ABIN307092, Supplier: Log in to see
Antigen
  • tau
  • xtp
  • MAPT
  • AI426939
  • AI551861
  • AW457082
  • CK1epsilon
  • CKIe
  • KC1epsilon
  • DDPAC
  • FTDP-17
  • MAPTL
  • MSTD
  • MTBT1
  • MTBT2
  • PPND
  • TAU
  • AI413597
  • AW045860
  • Mtapt
  • Tau
  • PHF-tau
  • RNPTAU
  • pTau
  • microtubule-associated protein tau
  • Microtubule-associated protein tau
  • casein kinase 1, epsilon
  • mapt
  • MAPT
  • AaeL_AAEL015538
  • AaeL_AAEL012206
  • CpipJ_CPIJ013260
  • tau
  • Csnk1e
  • Mapt
Epitope
pan
60
42
37
36
35
35
34
32
28
27
27
26
23
17
17
17
16
16
15
12
11
11
10
9
9
9
8
8
8
8
7
7
7
7
6
6
6
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus), Sheep (Ovine), Cow (Bovine)
981
626
602
130
46
44
42
33
24
16
11
9
4
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
Host
Mouse
881
138
11
7
Clonality (Clone)
Monoclonal ()
Conjugate
This MAPT antibody is un-conjugated
25
10
10
7
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
915
332
300
140
88
55
54
51
17
14
13
12
12
12
9
7
4
1
Options
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Available images

Clone TAU-5
Isotype IgG1
Alternative Name tau (MAPT Antibody Abstract)
Background This antibody recognizes proteins of 45-68 kDa, identified as tau proteins. Tau proteins promote the assembly of tubulin monomers into microtubules and stabilize microtubules. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau. The TAU-5 monoclonal antibody reacts with the non-phosphorylated as well as the phosphorylated forms of tau. Its epitope is located in the middle region of tau. This antibody is highly specific for tau and does not cross-react with other microtubule associated proteins (MAPs) or tubulin. In immunohistology, this antibody intensely stains the human neurofibrillary tangles, neuropil threads, and neuritic plaques associated with Alzheimer's disease. This antibody is also observed to stain astrocytes.
UniProt P10636
Pathways MAPK Signaling, Microtubule Dynamics, M Phase, Regulation of Cell Size
Application Notes The optimal antibody concentration should be determined for each specific application..For immunoprecipitation, use 10 g per 200-500 g of cell lysate, and for Western blotting, use 1 g/mL. For immunohistology, use 1-2 g/mL for 30-60 minutes at room temperature. Use antigen retreival for staining with paraffin embedded sections. . Positive Control: Human T98G glioblastoma, SH-SY5Y cells or brain tissue..
Restrictions For Research Use only
Concentration 0.5 mg/ml
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-MAPT antibody (Microtubule-Associated Protein tau) (pan) (ABIN307092) Extracts from SH-SY5Y neuronal cells incubated with 1:1000 dilution of the anti-tau a...
Background publications Takahashi, Saito, Hisanaga, Pant, Kulkarni: "Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10506-15, 2003 (PubMed).

Papasozomenos, Shanavas et al.: "Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 3, pp. 1140-5, 2002 (PubMed).

Rapoport, Dawson, Binder, Vitek, Ferreira: "Tau is essential to beta -amyloid-induced neurotoxicity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 9, pp. 6364-9, 2002 (PubMed).