Microtubule-Associated Protein tau (MAPT) (pan) antibody

Details for Product No. ABIN307092
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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Epitope
pan
(44), (33), (33), (30), (30), (30), (30), (26), (26), (26), (25), (25), (24), (23), (18), (13), (12), (11), (11), (11), (11), (10), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus), Sheep (Ovine), Cow (Bovine)
(859), (450), (427), (51), (8), (6), (3), (3), (2), (1), (1), (1), (1)
Host
Mouse
(802), (95), (10), (8), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(795), (347), (237), (91), (76), (60), (31), (29), (16), (13), (13), (13), (12), (9), (1), (1)
Pubmed 3 references available
Quantity 100 µg
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Catalog No. ABIN307092
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Clone TAU-5
Isotype IgG1
Alternative Name tau
Background This antibody recognizes proteins of 45-68 kDa, identified as tau proteins. Tau proteins promote the assembly of tubulin monomers into microtubules and stabilize microtubules. Alternate splicing of tau mRNA, glycosylation, and differential phosphorylation contribute to the heterogeneity of tau. The TAU-5 monoclonal antibody reacts with the non-phosphorylated as well as the phosphorylated forms of tau. Its epitope is located in the middle region of tau. This antibody is highly specific for tau and does not cross-react with other microtubule associated proteins (MAPs) or tubulin. In immunohistology, this antibody intensely stains the human neurofibrillary tangles, neuropil threads, and neuritic plaques associated with Alzheimer's disease. This antibody is also observed to stain astrocytes.
UniProt P10636
Application Notes The optimal antibody concentration should be determined for each specific application..For immunoprecipitation, use 10 g per 200-500 g of cell lysate, and for Western blotting, use 1 g/mL. For immunohistology, use 1-2 g/mL for 30-60 minutes at room temperature. Use antigen retreival for staining with paraffin embedded sections. . Positive Control: Human T98G glioblastoma, SH-SY5Y cells or brain tissue..
Restrictions For Research Use only
Concentration 0.5 mg/ml
Storage -20 °C
Supplier Images
anti-Microtubule-Associated Protein tau (MAPT) (pan) antibody Extracts from SH-SY5Y neuronal cells incubated with 1:1000 dilution of the anti-tau antibody. The signal was detected using a Goat F(ab’)2 anti-Mouse IgG Alkaline Phosphatase antibody at a 1:5000 dilution. and Membrane was incubated with CDP-substrate using the WesternStarTM method (Tropix).
General Papasozomenos, Shanavas: "Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3 beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 3, pp. 1140-5, 2002 (PubMed).

Rapoport, Dawson, Binder et al.: "Tau is essential to beta -amyloid-induced neurotoxicity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 9, pp. 6364-9, 2002 (PubMed).

Takahashi, Saito, Hisanaga et al.: "Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10506-15, 2003 (PubMed).

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