5mC antibody

Details for Product No. ABIN3071645, Supplier: Log in to see
Antigen
Reactivity
Human, Mouse (Murine)
Host
Mouse
Clonality
Monoclonal
Application
Chromatin Immunoprecipitation (ChIP)
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Specificity Recognises the C-terminal peptide of human histone H3.
Purification Protein G (affinity purified)
Background 5mC (5---Methylcytosine) is a region of DNA that has been epigenetically modified through the addition of a methyl group at the 5th carbon position of cytosine. DNA methylation is a repressive histone modification that is associated with switching off gene expression. This methylation generally occurs at CpG islands and is also associated with genomic imprinting. Aberrant DNA methylation is linked to disease including many cancers.
Application Notes Chromatrap technology: 1:4 (gDNA:antibody)
Please note: Optimal antibody dilutions should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple free/thaw cycles as this may denature the antibody
Storage -20 °C
Expiry Date 12 months
Supplier Images
Methylated DNA Immunoprecipitation (MeDIP) image for anti-5mC antibody (ABIN3071645) Methylated DNA Immunoprecipitation (MeDIP) assays were performed with 500ng of genomi...