TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa (TAF6) (N-Term) antibody

Details for Product No. ABIN309749
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Antigen
Synonyms
CG32211, CG9348, Dmel\\CG32211, SR3-4B, TAF, TAF6, TAF60, TAF60/62, TAFII60, TAFII60(62), TAFII62, TAF[[II]], TAF[[II]]60, TAF[[II]]60/62, TAF[[II]]62, TFIID, TFIID 62, Taf-6, Taf60, Taf62, Taf[[II]]6 ... show more
CG32211, CG9348, Dmel\\CG32211, SR3-4B, TAF, TAF6, TAF60, TAF60/62, TAFII60, TAFII60(62), TAFII62, TAF[[II]], TAF[[II]]60, TAF[[II]]60/62, TAF[[II]]62, TFIID, TFIID 62, Taf-6, Taf60, Taf62, Taf[[II]]60, d60, dTAF6, dTAF62, dTAFII62, dTAF[[II]]262, dTAF[[II]]60, dTAF[[II]]62, dmTAF6, dme-TAFII60, l(3)76BDf, p62, taf6, taf60, wu:fb83e08, wu:fj30b02, zgc:92160, 80kDa, AW549759, TAF(II)80, TAFII70, Taf2e, p80, TAF(II)60, MGC:8964, TAF(II)70, TAF2E, TAFII-70, TAFII-80, TAFII80, TAFII85 show less
Epitope
N-Term
(11), (7), (3), (2), (2), (2), (2)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Xenopus laevis, Human
(25), (3), (2), (2), (2), (1), (1)
Host
Rabbit
(22), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(25), (8), (7), (3), (3), (2), (2), (2), (2), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN309749
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Immunogen Synthetic peptide directed towards the N terminal of human TAF6
Sequence LTDEVSYRIK EIAQDALKFM HMGKRQKLTT SDIDYALKLK NVEPLYGFHA
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rat : 100 %, African clawed frog : 80 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against TAF6. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name TAF6
Background TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. TAF6 is one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1,the largest subunit of TFIID. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.
Molecular Weight 71 kDa
Gene ID 6878
NCBI Accession NP_620834, NM_139122
UniProt A4D2B3
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 667 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa (TAF6) (N-Term) antibody anti-TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa (TAF6) (N-Term) antibody
anti-TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa (TAF6) (N-Term) antibody (2) WB Suggested Anti-TAF6
Antibody Titration: 1.25 µg/mL
Positive Control: Transfected 293T
Product cited in: Lazrek, Goffard, Schanen et al.: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, 2006 (PubMed).

Background publications Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Validation Images
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