ZIC2 (ZIC2) (C-Term) antibody

Details for Product No. ABIN309795
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Antigen
Synonyms HPE5, cb851, fb26a03, wu:fb26a03, zic2, zic2.1, Ku
Epitope
C-Term
(6), (4), (3), (1), (1), (1)
Reactivity
Human
(24), (22), (16), (14), (12), (12), (4), (1)
Host
Rabbit
(23), (5), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(19), (12), (10), (3), (2), (1), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN309795
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human ZIC2
Sequence EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
Predicted Reactivity Human : 100 %, Pig : 80 %
Characteristics This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name ZIC2
Background ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Molecular Weight 55 kDa
Gene ID 7546
NCBI Accession NP_009060, NM_007129
UniProt O95409
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 532 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-ZIC2 (ZIC2) (C-Term) antibody WB Suggested Anti-ZIC2 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
anti-ZIC2 (ZIC2) (C-Term) antibody (2) anti-ZIC2 (ZIC2) (C-Term) antibody (Image 2)
anti-ZIC2 (ZIC2) (C-Term) antibody (3) Human Skin
Product cited in: McCampbell, Truong, Broom et al.: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, 2005 (PubMed).

Background publications Brown, Paraso, Arkell et al.: "In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation." in: Human molecular genetics, Vol. 14, Issue 3, pp. 411-20, 2005 (PubMed).

Validation Images
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