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Details for Product No. ABIN309795

ZIC2 (ZIC2) (C-Term) antibody

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Antigen
Synonyms cb851, fb26a03, wu:fb26a03, zic2, zic2.1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN309795
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-ZIC2 antibody: synthetic peptide directed towards the C terminal of human ZIC2
Sequence EPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGA GGGSGGGSGS
Predicted Reactivity Human : 100%, Pig : 85%
Characteristics This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry. We manufacture rabbit polyclonal antibodies on a large scale of high throughput manner. Our antibodies are peptide based and protein family oriented.
Purification Affinity Purified
Alternative Name ZIC2
Background ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Molecular Weight 55kDa
Gene ID 7546
NCBI Accession NP_009060, NM_007129
UniProt O95409
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-ZIC2 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Product cited in: McCampbell, Truong, Broom et al.: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, 2005 (PubMed).

Background publications Brown, Paraso, Arkell et al.: "In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation." in: Human molecular genetics, Vol. 14, Issue 3, pp. 411-20, 2005 (PubMed).

Alternatives for antigen "ZIC2 (ZIC2)", type "Antibodies"
Hosts (26), (5), (3)
Reactivities (27), (24), (16), (15), (13), (12), (5), (1), (1), (1), (1)
Applications (22), (18), (10), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (2), (1), (1)
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