Splicing Factor 3a, Subunit 3, 60kDa (SF3A3) (Middle Region) antibody

Details for Product No. ABIN310069
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Antigen
Synonyms 4930512K19Rik, 60kDa, LRRGT00093, PRP9, PRPF9, SAP61, SF3a60
Epitope
Middle Region
(2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Dog (Canine), Human, Chicken
(12), (4), (4)
Host
Rabbit
(10), (2)
Clonality
Polyclonal
Application
Western Blotting (WB)
(11), (7), (4), (3), (3), (2)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN310069
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Immunogen Synthetic peptide directed towards the middle region of human SF3A3
Sequence THENVQRKQA RTGEEREEEE EEQISESESE DEENEIIYNP KNLPLGWDGK
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against SF3A3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SF3A3
Background SF3A3 is the subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP.This This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.
Molecular Weight 59 kDa
Gene ID 10946
NCBI Accession NP_006793, NM_006802
UniProt Q12874
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 501 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Splicing Factor 3a, Subunit 3, 60kDa (SF3A3) (Middle Region) antibody WB Suggested Anti-SF3A3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: 721_B cell lysate
Product cited in: Ewing, Chu, Elisma et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, 2007 (PubMed).

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