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Lecithin-Cholesterol Acyltransferase (LCAT) (N-Term) antibody

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Antigen
Epitope
N-Term
(15), (13), (11), (11), (11), (8), (7), (6), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
(93), (41), (41), (3), (2), (1), (1)
Host
Rabbit
(115), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(15), (10), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(89), (58), (23), (21), (20), (18), (15), (12), (11), (2), (2), (1), (1)
Pubmed 2 references available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human LCAT
Sequence MGPPGSPWQW VTLLLGLLLP PAAPFWLLNV LFPPHTTPKA ELSNHTRPVI
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Sheep : 100 %
Characteristics This is a rabbit polyclonal antibody against LCAT. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name LCAT (LCAT Antibody Abstract)
Background LCAT is an extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in its gene have been found to cause fish-eye disease as well as LCAT deficiency.This gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency.
Molecular Weight 48 kDa
Gene ID 3931
NCBI Accession NP_000220, NM_000229
UniProt P04180
Research Area Cancer, Atherosclerosis, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 440 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Lecithin-Cholesterol Acyltransferase (LCAT) (N-Term) antibody (ABIN310203) WB Suggested Anti-LCAT Antibody Titration: 5.0ug/ml
Positive Control:
Product cited in: Hirata, Yimin, Segawa et al.: "Xanthohumol prevents atherosclerosis by reducing arterial cholesterol content via CETP and apolipoprotein E in CETP-transgenic mice." in: PLoS ONE, Vol. 7, Issue 11, pp. e49415, 2012 (PubMed).

Background publications Calabresi, Pisciotta, Costantin et al.: "The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 25, Issue 9, pp. 1972-8, 2005 (PubMed).

Catalog No. ABIN310203

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