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Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibody

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Antigen
Epitope
N-Term
(16), (1), (1), (1), (1)
Reactivity
Human
(11), (10), (3)
Host
Rabbit
(11), (11)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(19), (13), (7), (1)
Pubmed 3 references available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human SLC19A1
Sequence MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against SLC19A1. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name SLC19A1 (SLC19A1 Antibody Abstract)
Background Transport of folate compounds into mammalian cells can occur via receptor-mediated or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. SLC19A1 plays a role in maintaining intracellular concentrations of folate.Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.
Molecular Weight 65 kDa
Gene ID 6573
NCBI Accession NP_919231, NM_194255
UniProt P41440
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 591 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Solute Carrier Family 19 (Folate Transporter), Member 1 (SLC19A1) (N-Term) antibody (ABIN310565) WB Suggested Anti-SLC19A1 Antibody Titration: 5.0ug/ml
Positive Control:...
Product cited in: Halwachs, Lakoma, Schäfer et al.: "The antiepileptic drugs phenobarbital and carbamazepine reduce transport of methotrexate in rat choroid plexus by down-regulation of the reduced folate carrier." in: Molecular pharmacology, Vol. 80, Issue 4, pp. 621-9, 2011 (PubMed).

Marchi, Paoluzzi, Scotto et al.: "Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 14, pp. 3648-58, 2010 (PubMed).

Background publications Payton, Liu, Ge et al.: "Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors." in: Biochimica et biophysica acta, Vol. 1731, Issue 2, pp. 115-24, 2005 (PubMed).

Catalog No. ABIN310565

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