anti-CENPA antibody (Centromere Protein A) (N-Term)

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Antigen
Epitope
N-Term
(22), (15), (15), (14), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(133), (6), (4), (2), (1), (1), (1)
Host
Rabbit
(84), (45), (5)
Clonality
Polyclonal
Conjugate
This CENPA antibody is un-conjugated
(5), (5), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(95), (47), (26), (16), (13), (12), (7), (3), (3), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the N terminal of human CENPA
Sequence MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against CENPA. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name CENPA (CENPA Antibody Abstract)
Background Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA is a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.
Molecular Weight 16 kDa
Gene ID 1058
NCBI Accession NM_001809, NP_001800
UniProt P49450
Research Area Chromatin and Nuclear Signaling, Cell Cycle
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 140 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-CENPA antibody (Centromere Protein A) (N-Term) (ABIN310757) anti-Centromere Protein A (CENPA) (N-Term) antibody
Immunohistochemistry (IHC) image for anti-CENPA antibody (Centromere Protein A) (N-Term) (ABIN310757) anti-Centromere Protein A (CENPA) (N-Term) antibody (Image 2)
Background publications Black, Foltz, Chakravarthy et al.: "Structural determinants for generating centromeric chromatin." in: Nature, Vol. 430, Issue 6999, pp. 578-82, 2004 (PubMed).

Catalog No. ABIN310757
$229.00
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