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MAFK antibody (N-Term)

MAFK Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Sheep WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN310919
  • Target See all MAFK Antibodies
    MAFK (Transcription Factor MafK (MAFK))
    Binding Specificity
    • 7
    • 6
    • 6
    • 3
    N-Term
    Reactivity
    • 27
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Guinea Pig, Zebrafish (Danio rerio), Dog, Horse, Rabbit, Sheep
    Host
    • 25
    • 2
    Rabbit
    Clonality
    • 25
    • 2
    Polyclonal
    Conjugate
    • 12
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    This MAFK antibody is un-conjugated
    Application
    • 21
    • 16
    • 14
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    KEAGENAPVL SDDELVSMSV RELNQHLRGL TKEEVTRLKQ RRRTLKNRGY
    Predicted Reactivity
    Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%, Sheep: 79%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against MAFK. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human MAFK
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  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 156 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    MAFK (Transcription Factor MafK (MAFK))
    Alternative Name
    MAFK (MAFK Products)
    Synonyms
    NFE2U antibody, P18 antibody, AW061068 antibody, NF-E2 antibody, Nfe2u antibody, MAF bZIP transcription factor K antibody, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) antibody, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K antibody, Mafk antibody, MAFK antibody, mafk antibody
    Background
    The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2. NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, PBGD and FECH. NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG, or MafK) and p45. Both subunits are members of the activator protein-1 superfamily of bZIP proteins. Maf homodimers suppress transcription at NFE2 sites.The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD, MIM 176000) and ferrochelatase (FECH, MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM].
    Alias Symbols: FLJ32205, MGC71717, NFE2U, P18
    Protein Interaction Partner: NFE2L2, SMAD3, PARP1, HIF1A, UBC, SUMO2, Bach1, HDAC3, HDAC2, HDAC1, CREBBP, RELA, KAT6A, TP53, BACH2, NFE2L3, NFE2, MARS, MAFK, NFE2L1, HOXD12,
    Protein Size: 156
    Molecular Weight
    17 kDa
    Gene ID
    7975
    NCBI Accession
    NM_002360, NP_002351
    UniProt
    O60675
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