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Prohibitin 2 antibody (C-Term)

PHB2 Reactivity: Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Pig WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN311023
  • Target See all Prohibitin 2 (PHB2) Antibodies
    Prohibitin 2 (PHB2)
    Binding Specificity
    • 16
    • 8
    • 8
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 75
    • 39
    • 13
    • 11
    • 8
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Guinea Pig, Cow, Dog, Pig
    Host
    • 73
    • 2
    • 2
    Rabbit
    Clonality
    • 73
    • 4
    Polyclonal
    Conjugate
    • 47
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Prohibitin 2 antibody is un-conjugated
    Application
    • 66
    • 27
    • 22
    • 18
    • 16
    • 13
    • 13
    • 11
    • 10
    • 9
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    KLRKIRAAQN ISKTIATSQN RIYLTADNLV LNLQDESFTR GSDSLIKGKK
    Predicted Reactivity
    Cow: 100%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against PHB2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C terminal region of human PHB2
    Top Product
    Discover our top product PHB2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 299 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    Prohibitin 2 (PHB2)
    Alternative Name
    PHB2 (PHB2 Products)
    Synonyms
    bcap37 antibody, zgc:73150 antibody, wu:fc28c08 antibody, PHB2 antibody, phb2 antibody, ATPHB2 antibody, F21M11.21 antibody, F21M11_21 antibody, prohibitin 2 antibody, DKFZp469N1310 antibody, BAP antibody, BCAP37 antibody, Bap37 antibody, PNAS-141 antibody, REA antibody, p22 antibody, bap37 antibody, prohibitin2 antibody, xphb2 antibody, AU044498 antibody, Bcap37 antibody, Bap antibody, Bap-37 antibody, Bcap27 antibody, prohibitin 2a antibody, prohibitin 2 antibody, prohibitin 2 S homeolog antibody, phb2a antibody, PHB2 antibody, phb2 antibody, phb2.S antibody, Phb2 antibody
    Background
    PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It probably involved in regulating mitochondrial respiration activity and in aging.
    Alias Symbols: BAP, BCAP37, Bap37, MGC117268, PNAS-141, REA, p22
    Protein Interaction Partner: HUWE1, IGF1R, HDAC1, ESR1, KIAA1244, NCOR1, SUMO2, STAU1, UBC, MDM2, ASB14, ASB17, SUZ12, EED, RNF2, UPF2, ADRB2, CDK2, env, VCAM1, TEAD3, ITGA4, ILF3, FN1, ATF2, C1QBP, AFP, UBL4A, EPAS1, FMNL1, PAXIP1, MDC1, MYOD1, MEF2A, FHL2, ECT2, BRCA1, AKT1, Htt, U
    Protein Size: 299
    Molecular Weight
    33 kDa
    Gene ID
    11331
    NCBI Accession
    NM_007273, NP_009204
    UniProt
    Q99623
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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