Sulfatase 2 (SULF2) (C-Term) antibody

Details for Product No. ABIN311170
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Antigen
Epitope
C-Term
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Xenopus laevis, Human, Chicken
Host
Rabbit
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN311170
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Immunogen Synthetic peptide directed towards the C terminal of human SULF2
Sequence DVLNQLHVQL MELRSCKGYK QCNPRTRNMD LGLKDGGSYE QYRQFQRRKW
Predicted Reactivity Dog : 100 %, Horse : 100 %, Human : 100 %, Rabbit : 100 %, Chicken : 90 %, Mouse : 90 %, Rat : 90 %, African clawed frog : 70 %, Bovine : 70 %
Characteristics This is a rabbit polyclonal antibody against SULF2. It was validated on Western Blot and immunohistochemistry.
Purification Protein A purified
Alternative Name SULF2
Background Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules.Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).
Molecular Weight 98 kDa
Gene ID 55959
NCBI Accession NM_018837, NP_061325
UniProt Q8IWU5
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 870 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Sulfatase 2 (SULF2) (C-Term) antibody anti-Sulfatase 2 (SULF2) (C-Term) antibody
anti-Sulfatase 2 (SULF2) (C-Term) antibody (2) anti-Sulfatase 2 (SULF2) (C-Term) antibody (Image 2)
Product cited in: Uchimura, Morimoto-Tomita, Bistrup et al.: "HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1." in: BMC biochemistry, Vol. 7, pp. 2, 2006 (PubMed).

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