Protocadherin alpha 10 (PCDHA10) (N-Term) antibody

Details for Product No. ABIN311172
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Antigen
Epitope
N-Term
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Human
Host
Rabbit
Clonality
Polyclonal
Application
Western Blotting (WB)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN311172
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Immunogen Synthetic peptide directed towards the N terminal of human PCDHA10
Sequence DKDKFPVLVL RKLLDREENP QLKLLLTATD GGKPEFTGSV SLLILVLDAN
Predicted Reactivity Rat : 100 %, Dog : 90 %
Characteristics This is a rabbit polyclonal antibody against PCDHA10. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCDHA10
Background This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Molecular Weight 73 kDa
Gene ID 56139
NCBI Accession NM_031860, NP_114066
UniProt A1L493
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 685 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Protocadherin alpha 10 (PCDHA10) (N-Term) antibody WB Suggested Anti-PCDHA10 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
Background publications Schmutz, Martin, Terry et al.: "The DNA sequence and comparative analysis of human chromosome 5. ..." in: Nature, Vol. 431, Issue 7006, pp. 268-74, 2004 (PubMed).

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