Protocadherin gamma Subfamily A, 4 (PCDHGA4) (N-Term) antibody

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Antigen
Synonyms PCDH-GAMMA-A4, Pcdhga3, PCDHGA4
Epitope
N-Term
(3), (1), (1)
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(6), (4), (4)
Host
Rabbit
(5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1)
Application
Western Blotting (WB)
(5), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human PCDHGA4
Blocking Peptide Blocking peptide for this product available: Protocadherin gamma Subfamily A, 4 (PCDHGA4) peptide (ABIN981459)
Sequence GDPVRSGTAR ILIILVDTND NAPVFTQPEY HVSVRENVPV GTRLLTVKAT
Predicted Reactivity Mouse : 100 %
Characteristics This is a rabbit polyclonal antibody against PCDHGA4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PCDHGA4 (PCDHGA4 Antibody Abstract)
Background PCDHGA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Molecular Weight 86 kDa
Gene ID 56111
NCBI Accession NP_114442, NM_032053
Research Area Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 820 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Protocadherin gamma Subfamily A, 4 (PCDHGA4) (N-Term) antibody (ABIN311175) WB Suggested Anti-PCDHGA4 Antibody Titration: 0.2-1 ug/ml
Positive Contr...
Background publications Wu, Zhang, Cheng et al.: "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters." in: Genome research, Vol. 11, Issue 3, pp. 389-404, 2001 (PubMed).

Catalog No. ABIN311175
$289.00
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