Inhibitor of Growth Family, Member 1 (ING1) (C-Term) antibody

Details for Product No. ABIN311312
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Antigen
Synonyms p33, p47, p33ING1, p24ING1c, p33ING1b, p47ING1a, p33ING1c, 2610028J21Rik, AA407184, AI875420, mING1h, p33Ing1, p37Ing1b, ING1, si:busm1-40g1.1, si:dz40g1.1, wu:fc94a02, zgc:100910, xing1, zgc:136918
Epitope
C-Term
(10), (6), (2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Human
(41), (27), (17)
Host
Rabbit
(30), (9), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(34), (25), (10), (9), (7), (4), (4), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN311312
Quantity 100 µg
Price
229.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the C terminal of human ING1
Sequence EKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQ VSYGEMIGCD
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, Chicken : 90 %, Horse : 90 %, Rabbit : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against ING1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name ING1
Background ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of ING1 gene have been detected in various cancers.This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
Molecular Weight 32 kDa
Gene ID 3621
NCBI Accession NM_198219, NP_937862
UniProt Q5T9H0
Research Area Cancer, Transcription Factors, Apoptosis/Necrosis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 279 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Inhibitor of Growth Family, Member 1 (ING1) (C-Term) antibody WB Suggested Anti-ING1 Antibody Titration: 2.5ug/ml
Positive Control: HepG2 cell lysate
Background publications Ahmed, Kelly, Anderson et al.: "The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer." in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, Vol. 10, Issue 4, pp. 344-51, 2008 (PubMed).

Hosts (30), (9), (7)
Reactivities (41), (27), (17)
Applications (34), (25), (10), (9), (7), (4), (4), (2), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (6), (2), (1), (1), (1)
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