Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (Alexa Fluor 488)

Antigen: Lysosomal-Associated Membrane Protein 1 (LAMP1)

Synonyms: LAMPA, CD107a, LGP120

Clonality: Monoclonal (H4A3)

Host: Mouse

Reactivity: Human

Conjugate: Alexa Fluor 488

Application: Flow Cytometry (FACS)

Catalog no.: ABIN311773

Additional Information

Alternative name: CD107a (LAMP-1)

Isotype: IgG1, kappa chain

Clone: H4A3

Description: CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type Imembrane gly-coprotein. The mature CD107a is heavily glycosylated from a 40 kD core protein. It is expressed byactivated platelets, acti-vated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells.This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection oflysosome membrane from lysosomal hydrolases. Upon activation, CD107a is transferred to the cell membranesurface. It plays a role in cell adhesion and regula-tion of tumor metastasis, and mediates autoimmune diseaseprogression. CD107a is a ligand for galaptin and E-selectin.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor

Purification: The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 488 under optimal conditions. The solution is free of unconjugated Alexa Fluor 488.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only