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Antibodies
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anti-Interleukin 17A (IL17A) antibody (Alexa Fluor 488)
Interleukin 17A (IL17A) antibody (Alexa Fluor 488)
| Antigen |
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| Synonyms |
IL17, CTLA8, IL-17, IL-17A, Il17, Ctla8, Ctla-8, IL17F, IL17A, ChIL-17 |
| Clonality |
Monoclonal (BL168) |
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Host
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Reactivity
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Conjugate
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Application
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| Catalog no. |
ABIN311783 |
| Quantity |
25 tests (Variants) |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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IL-17A
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Immunogen
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Recombinant full length human IL-17A
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Isotype
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IgG1, kappa chain
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Clone
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BL168
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Description
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IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines.IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cellsincluding: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts, theenhancement of surface expression of ICAM-1 in fibroblasts, activation of NF-kappaB and costimulation of T cellproliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells)mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). HumanIL-17A shows 63%, 63% and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A and a protein encodedby the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
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Application Notes
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Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul ofwhole blood. It is recommended that the reagent be titrated for optimalperformance for each application.* Alexa Fluor
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Purification
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The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 488 under optimal conditions. The solution is free of unconjugated Alexa Fluor 488.
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Buffer
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Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).
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Storage
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The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.
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Restrictions
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For Research Use only
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Alternatives for antigen "Interleukin 17A (IL17A)", type "Antibodies"
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Hosts
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Rabbit (13), Mouse (12), Rat (8), Goat (4)
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Reactivities
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Human (25), Mouse (Murine) (12), Rat (Rattus) (3)
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Applications
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Western Blotting (WB) (26), Enzyme Immunoassay (EIA) (21), Flow Cytometry (FACS) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), ELISA (4), Functional Studies (Func) (3), Neutralization (Neut) (3), Immunofluorescence (IF) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
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Conjugates
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Biotin (7), Alexa Fluor 647 (4), PE (2), Alexa Fluor 488 (1)
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Epitopes
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AA 20-155 (1), Center (1), N-Term (1)
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Alternatives 
