CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) antibody (Alexa Fluor 647)

Antigen: CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40)

Synonyms: p50, Bp50, CDW40, MGC9013, TNFRSF5, IGM, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, CD40

Clonality: Monoclonal (5C3)

Host: Mouse

Reactivity: Human

Conjugate: Alexa Fluor 647

Application: Flow Cytometry (FACS)

Catalog no.: ABIN311858

Additional Information

Alternative name: CD40

Isotype: IgG1, kappa chain

Clone: 5C3

Description: CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressedon B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells.CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protectionof B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154(CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 orPMA, partially block CD40 binding to CD40L and rescue B cells from apoptosis.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 5 ul per million cells or 5 ul per 100 ul of wholeblood. It is recommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor

Purification: The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor 647.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and0.2% (w/v) BSA (origin USA).

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only