Notch 4 (NOTCH4) antibody (Alexa Fluor 647)

Antigen: Notch 4 (NOTCH4)

Synonyms: INT3, NOTCH3, FLJ16302, MGC74442, NOTCH4

Clonality: Monoclonal (HMN4-14)

Host: Hamster

Reactivity: Mouse (Murine)

Conjugate: Alexa Fluor 647

Application: Flow Cytometry (FACS)

Catalog no.: ABIN311992

Additional Information

Alternative name: Notch 4

Immunogen: Notch4-Fc recombinant protein

Isotype: IgG

Clone: HMN4-14

Description: The Notch receptors are highly conserved from invertebrates to mammals. Notch 4 is one of the 4 Notchhomologues. Notch receptors are activated after binding to its ligands. The binding results in the proteolysis of Notchand movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signalingprocess. Notch 4 is an endothelial cell specific homologue of Notch and it may play a crucial role in vasculogenesisand angiogenesis.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is approx. 1.0 ug/test. It is recommended that thereagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 647 under optimal conditions. The solution is free of unconjugated Alexa Fluor 647.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only