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T-Bet antibody (Alexa Fluor 647)
| Antigen | T-Bet |
| Clonality | Monoclonal (4B10) |
| Host |
Mouse |
| Reactivity |
Human, Mouse (Murine) |
| Conjugate |
Alexa Fluor 647
|
| Application |
Intracellular Flow Cytometry (ICFC)
|
| Catalog no. | ABIN311998 |
| Quantity | 25 ug (Variants) |
| Price | Product not available in this region. |
| Shipping to |
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Additional Information
| Isotype | IgG1 |
| Clone | 4B10 |
| Description | T-bet, also known as T-box transcription factor T-bet, is considered to be a "master regulator" of Th1 lymphoiddevelopment controlling the production of the cytokine IFN-gamma. T-bet is widely expressed in hematopoietic cellsincluding stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens and knockoutanimals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimallyobserved after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12. |
Application Details
| Application Notes | Each lot of this antibody is quality control tested by immunofluorescentstaining with flow cytometric analysis. For immunofluorescent staining, thesuggested use of this reagent is 1.0 ug per ml. It is recommended that thereagent be titrated for optimal performance for each application. |
| Purification | The antibody was purified by affinity chromatography. |
| Buffer | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Storage | The antibody solution should be stored undiluted at 4 degrees C. |
| Restrictions | For Research Use only |
