Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1) antibody (Alexa Fluor 700)

Antigen: Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1)

Synonyms: KIR, NKB1, NKAT3, NKB1B, CD158E1, MGC119726, MGC119728, MGC126589, MGC126591, Krl1, Kirl1, Kirl2, KIR3DL1, KIR3DL3

Clonality: Monoclonal (DX9)

Host: Mouse

Reactivity: Human

Conjugate: Alexa Fluor 700

Application: Flow Cytometry (FACS)

Catalog no.: ABIN312015

Additional Information

Alternative name: CD158e1 (KIR3DL1, NKB1)

Immunogen: Human NK cell clone VL186-1.6

Isotype: IgG1, kappa chain

Clone: DX9

Description: The DX9 antibody reacts with the KIR (killer cell inhibitory receptor) designated NKB1 or KIR3DL1. NKB1 is a 70 kDmember of the immunoglobulin superfamily that is expressed on a subset of natural killer cells and T cells at varyinglevels among individuals. NKB1 is a type I membrane protein containing two immunoglobulin C2-type domains. Theinteraction of NKB1 with specific HLA-B antigens on a target cell (the HLA-Bw4 allele, for example) inhibitscytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to beimportant in NK and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower thethreshold for activation through activating receptors and increase inflammation and susceptibility to autoimmunedisease.

Application Details

Application Notes: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is approx. 0.5 ug per 106 cells in 100 ul volume. It isrecommended that the reagent be titrated for optimal performance for each application.* Alexa Fluor

Purification: The antibody was purified by affinity chromatography, and conjugated withAlexa Fluor 700 under optimal conditions. The solution is free of unconjugated Alexa Fluor 700.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4 degrees C and protected from prolonged exposure to light. Do not freeze.

Restrictions: For Research Use only