TEK Tyrosine Kinase, Endothelial (TEK) antibody (Biotin)

Antigen: TEK Tyrosine Kinase, Endothelial (TEK)

Synonyms: TIE2, VMCM, TIE-2, VMCM1, CD202B, MGC139569, TEK, DKFZp469E064

Clonality: Monoclonal (TEK4)

Host: Rat

Reactivity: Mouse (Murine)

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Catalog no.: ABIN312284

Additional Information

Alternative name: CD202b (Tie-2, CD202)

Isotype: IgG1 kappa

Clone: TEK4

Description: CD202b is a 145 kD type I transmembrane protein, also known as Tie-2 or TEK. It is a member of the receptortyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescenthematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator ofCD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 isanother ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2also binds to Ang-4.

Application Details

Application Notes: Each lot of this antibody is quality tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is approx. 0.5 ug per 106 cells in 100 ul volume. It isrecommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. Thesolution is free of unconjugated biotin.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4 degrees C. Do not freeze.

Restrictions: For Research Use only